A novel function of a mitochondrial enzyme in early development of African clawed frog.

• Project/Area Number: 22570204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Yamaguchi University
• Principal Investigator: IWAO Yasuhiro 山口大学, 大学院・医学系研究科, 教授 (10144916)
• Co-Investigator(Kenkyū-buntansha): UENO Shuichi 山口大学, 大学院・医学系研究科, 准教授 (80363092)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 細胞分化 / 細胞周期 / 細胞分裂 / クエン酸合成酵素 / 細胞骨格 / Caイオン / 初期胚細胞周期 / 分裂装置

Research Abstract

In this study, we tried to clarify the function of mitochondrial enzymes in the cytoplasm outside mitochondria, with particular attention to a novel molecular mechanism of cellular differentiation in differentiated tissues and organs. We found the distribution and behavior of citrate synthase and the molecules interacting with it during mid-blastula transition and gastrulation.

Research Products

• [Presentation] ツメガエル胚の MBT 期に出現する P-body における母性 mRNA 分解機構 (2012)
  • Author(s): 上野秀一
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 2012-12-13
• [Presentation] A novel role of extramitochondiral citrate synthase during Xenopus early embryonic development (2010)
  • Author(s): 岩尾康宏
  • Organizer: 第43回日本発生生物学会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-21
• [Presentation] A novel role of extramitochondiral citrate synthase during Xenopus early embryonic development (2010)
  • Author(s): 岩尾康宏
  • Organizer: 第43回日本発生生物学会
  • Place of Presentation: 京都市・国立京都国際会館
  • Year and Date: 2010-06-21
• [Presentation] ツメガエル胚の MBT 期に出現する P-body における母性 mRNA 分解機構
  • Author(s): 上野秀一
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac/.jpsuenoscb/index.html
• [Remarks] 山口大学理学部発生生物学研究室
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~suenoscb/index.html
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~suenoscb/index.html
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~suenoscb/index.html