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Evolutionary analysis of regeneration using echinoderms

Research Project

Project/Area Number 22570211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionThe University of Tokyo

Principal Investigator

KONDO Mariko  東京大学, 理学(系)研究科(研究院), 准教授 (70372414)

Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords再生 / 棘皮動物 / Hox / 進化 / 遺伝子 / 発生・分化
Research Abstract

We are studying regeneration in the feather star, since echinoderms exhibit a strong capacity for regeneration, and feather stars are reported to regenerate most of its body parts. Though there have been morphological or histological studies on echinoderm regeneration, only few have dealt with the molecular basis of regeneration. To study the evolution of regeneration, such molecular approach is necessary. We have isolated several genes from the feather star, and analyzed the expression of these genes during regeneration to test their involvement. Our data showed that there are undifferentiated cells in the arm that may be recruited for regeneration, using stem cell marker genes. Expression of genes involved in specification of anterior-posterior (Hox genes) and distal-proximal (RA-related genes) were found in the regenerating arm, and these may specify the character of the regenerating tissue. These results indicate the presence of a conserved mechanism in animal regeneration.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (21 results)

  • [Journal Article] Current Status of Echinoderm Genome Analysis - What Do We Know?2012

    • Author(s)
      Kondo, M. and Akasaka, K.
    • Journal Title

      Current Genomics

      Volume: 13 Issue: 2 Pages: 134-143

    • DOI

      10.2174/138920212799860643

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration in crinoids2010

    • Author(s)
      Kondo M, Akasaka K
    • Journal Title

      Dev Growth Differ

      Volume: 52 Issue: 1 Pages: 57-68

    • DOI

      10.1111/j.1440-169x.2009.01159.x

    • NAID

      10027563051

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ciona intestinalis and Oxycomanthus japonicus, Representatives of Marine Invertebrates2009

    • Author(s)
      Sasakura Y, Inaba K, Satoh N, Kondo M, Akasaka K
    • Journal Title

      Experimental Animals

      Volume: 58 Issue: 5 Pages: 459-469

    • DOI

      10.1538/expanim.58.459

    • NAID

      130000122256

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] マナマコの神経系の発生と五放射相称の形成2014

    • Author(s)
      永井晶子、菊池摩仁、大森紹仁、近藤真理子
    • Organizer
      日本動物学会第66回関東支部大会
    • Place of Presentation
      東京大学柏キャンパス(柏市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of the nervous system in a sea cucumber, Apostichopus japonicus: shift from bilateral to pentaradial symmetry2014

    • Author(s)
      Akiko Nagai, Mani Kikuchi, Akihito Omori, Koji Akasaka, Mariko Kondo
    • Organizer
      Developmental Biology of the Sea Urchin XXII
    • Place of Presentation
      Marine Biological Laboratories (Woods Hole, MA, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マナマコにおける成体神経発生2013

    • Author(s)
      永井晶子,菊池摩仁,大森紹仁,赤坂甲治,近藤真理子
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] マナマコにおける成体神経発生2013

    • Author(s)
      永井 晶子,菊池 摩仁,大森 紹仁,赤坂 甲治,近藤 真理子
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gene expression during regeneration of an echinoderm, Oxycomanthus japonicus2012

    • Author(s)
      Mariko Kondo, Shusaku Ueda, Rikai Sawafuji, Toko Tsurugaya, Akihito Omori, Koji Akasaka
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression during regeneration of a crinoid, Oxycomanthus japonicus2012

    • Author(s)
      Kondo M, Ueda S, Sawafuji R, Tsurugaya T, Omori A, Akasaka K.
    • Organizer
      Developmental Biology of the Sea Urchin XXI
    • Place of Presentation
      Woods Hole, MA 02543, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] ニッポンウミシダ再生過程における遺伝子発現の解析2012

    • Author(s)
      上田修作,大森紹仁,鶴ヶ谷柊子,赤坂甲治,近藤真理子
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Genomic and regeneration studies on a crinoid, Oxycomanthus japonicus2012

    • Author(s)
      Kondo M., Tsurugaya T., Ueda S., Sawafuji R., Omori A., Sumiyoshi N. and Akasaka K.
    • Organizer
      14th International Echinoderm Conference
    • Place of Presentation
      The Royal Academy of Sciences of Belgium, Brussels, Belgium
    • Related Report
      2013 Final Research Report
  • [Presentation] Use of a crinoid, Oxycomanthus japonicus in development, genomic, and regeneration studies2011

    • Author(s)
      Mariko Kondo, T.Tsurugaya, R.Sawafuji, N.Sumiyoshi, A.Ormri, T.Ikuta, T.Ota, K.Ikeo, H.Saiga, K.Akasaka
    • Organizer
      Joint Meeting of the German and Japanese Societies of Developmental Biologists
    • Place of Presentation
      ドレスデン工科大学(ドレスデン、ドイツ)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Use of a crinoid, Oxycomanthus japonicus in genomic and regeneration studies2011

    • Author(s)
      Mariko Kondo
    • Organizer
      JAMBIO Forum
    • Place of Presentation
      筑波大学下田臨海実験センター(下田市)(招待講演)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本ウミシダ再生過程におけるレチノイン酸遺伝子の発現2011

    • Author(s)
      上田修作、大森紹仁、澤藤りかい、池田つぼみ、井上祐介、赤坂甲治、近藤真理子
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Related Report
      2013 Final Research Report
  • [Presentation] 棘皮動物ニッポンウミシダのHoxクラスター構造の解析2011

    • Author(s)
      Mariko Kondo, Shusaku Ueda, Rikai Sawafuji, Toko Tsurugaya, Akihito Omori, Koji Akasaka
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 棘皮動物日本ウミシダ再生過程におけるレチノイン酸遺伝子の発現2011

    • Author(s)
      上田修作、大森紹仁、澤藤りかい、池田つぼみ、井上祐介、赤坂甲治、近藤真理子
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール(旭川)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊、赤坂甲治
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊、赤坂甲治
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 棘皮動物ニッポンウミシダの再生過程におけるvasa遺伝子の発現2010

    • Author(s)
      澤藤りかい、直良悠子、赤坂甲治、近藤真理子
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊、赤坂甲治
    • Organizer
      第12回日本進化学会大会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都)
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 赤坂甲治棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 棘皮動物ニッポンウミシダの再生過程におけるvasa遺伝子の発現2010

    • Author(s)
      澤藤りかい、直良悠子、赤坂甲治、近藤真理子
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 赤坂甲治棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 赤坂甲治棘皮動物ニッポンウミシダのHoxクラスター構造の解析2010

    • Author(s)
      近藤真理子、鶴ヶ谷柊子、住吉範子、生田哲朗、大田竜也、池尾一穂、西駕秀俊
    • Organizer
      第12回日本進化学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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