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Evolution of retinoic acid-dependent developmental regulatory system in chordates

Research Project

Project/Area Number 22570214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionKochi University

Principal Investigator

FUJIWARA Shigeki  高知大学, 教育研究部自然科学系, 教授 (40229068)

Co-Investigator(Renkei-kenkyūsha) SASAKURA Yasunori  筑波大学, 生命環境科学研究科, 准教授 (10400649)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsレチノイン酸 / Hox1 / 進化 / 遺伝子発現制御 / 脊索動物 / 遺伝子発現調節
Research Abstract

We demonstrated that retinoic acid activates expression of the Hox1 gene in ascidian embryos. We also showed that retinoic acid and Hox1 contributed to organogenesis of ascidian larvae. The larvacean Oikopleura dioica does not have retinoic acid synthase and retinoic acid receptor in their genome, even though it is a close relative of ascidians. We found in the present study that both larvaceans and ascidians have retinoic acid-independent mechanism to activate transcription of Hox1. We hypothesized that the common ancestor of larvaceans and ascidians had both retinoic acid-dependent and independent pathways for the Hox1 activation. Larvaceans are thought to have survived the loss of retinoic acid-related genes, probably because they had two redundant pathways.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (22 results) (of which Invited: 1 results)

  • [Journal Article] Identification of a retinoic acid-responsive neural enhancer in the Ciona intestinalis Hoxl gene.2013

    • Author(s)
      Kanda M, Ikeda T, Fujiwara S.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 55(2) Issue: 2 Pages: 260-269

    • DOI

      10.1111/dgd.12033

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid-driven Hoxl is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis.2012

    • Author(s)
      Yasunori Sasakura
    • Journal Title

      Development

      Volume: (印刷中) Issue: 12 Pages: 2156-2160

    • DOI

      10.1242/dev.080234

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RACK1 regulates mesenchymal cell recruitment during sexual and asexual reproduction of budding tunicates2012

    • Author(s)
      Tatzuke, Y., Sunanaga, T., Fujiwara, S.& Kawamura, K.
    • Journal Title

      Dev. Biol

      Volume: Vol. 368 Issue: 2 Pages: 393-403

    • DOI

      10.1016/j.ydbio.2012.06.006

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins.2012

    • Author(s)
      Sogame, Y.
    • Journal Title

      FEMS Microbiol. Lett.

      Volume: 331 Issue: 2 Pages: 128-135

    • DOI

      10.1111/j.1574-6968.2012.02560.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteia phosphorylation in encystment-induced Colpoda cucullus : Localization and identification of phosphoproteins2012

    • Author(s)
      Sogame, Y.
    • Journal Title

      FEMS Microbiology Letters

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placode during ascidian metamorphosis2012

    • Author(s)
      Sasakura, Y.
    • Journal Title

      Development

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and function of myc during asexual reproduction of the budding ascidian, Polyandrocarpa misakiensis2011

    • Author(s)
      Fujiwara, S., Isozaki, T., Mori, K., Kawamura, K.
    • Journal Title

      Dev.Growth Differ.

      Volume: 53 Issue: 9 Pages: 1004-1014

    • DOI

      10.1111/j.1440-169x.2011.01312.x

    • NAID

      10030404228

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ANISEED database : digital representation, formalization, and elucidation of a chordate developmental program2010

    • Author(s)
      O. Tassy, D. Dauga, F. Daian, D. Sobral, F. Robin, P. Khoueiry, D. Salgado, V Fox, D. Caillol, R. Schiappa, B. Laporte, A. Rios, G. Luxardi, T. Kusakabe, J. S. Joly, S. Darras, L. Christiaen, M. Contensin, H. Auger, C. Lamy, C. Hudson, U. Rothbacher, M. J. Gilchrist, K. W. Makabe, K. Hotta, S. Fujiwara, N. Satoh, Y Satou and P Lemaire
    • Journal Title

      Genome Res

      Volume: 20 Issue: 10 Pages: 1459-1468

    • DOI

      10.1101/gr.108175.110

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of chondroitin/dermatan sulfotransferases in the protochordate, Ciona intestinalis2010

    • Author(s)
      Tetsukawa, A., Nakamura, J. & Fujiwara, S.
    • Journal Title

      Comp. Biochem. Physiol

      Volume: Part B Vol. 157 Issue: 2 Pages: 205-212

    • DOI

      10.1016/j.cbpb.2010.06.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of the gut requires retinoic acid in the budding ascidian Polyandrocarpa misakiensis2010

    • Author(s)
      Kaneko, N., Katsuyama, Y., Kawamura, K. & Fujiwara, S.
    • Journal Title

      Dev. Growth Differ

      Volume: Vol. 52 Issue: 5 Pages: 457-468

    • DOI

      10.1111/j.1440-169x.2010.01184.x

    • NAID

      10027565188

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of the gut requires retinoic acid in the budding ascidian Polyandrocarpa misakiensis.2010

    • Author(s)
      Kaneko, N.
    • Journal Title

      Dev, Growth Differ.

      Volume: 52 Pages: 457-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of chondroitin/dermatan sulfotransferases in the protochordate, Ciona intestinalis.2010

    • Author(s)
      Tetsukawa, A.
    • Journal Title

      Comp.Biochem.Physiol.Part B

      Volume: 157 Pages: 205-212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ANISEED database : digital representation, formalization and elucidation of a chordate developmental program.2010

    • Author(s)
      Tassy, O.
    • Journal Title

      Genome Research

      Volume: 20 Pages: 1459-1468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transcriptional regulatory mechanism of the Hox1 gene in Ciona intestinalis and Oikopleura dioica2012

    • Author(s)
      Kanda, M., Canestro, C., Ikeda, T. &Fujiwara, S
    • Organizer
      Asia-Pacific Developmental Biology Conference
    • Place of Presentation
      台北市, 台湾
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] カタユウレイボヤ胚におけるグリコサミノグリカン硫酸転移酵素の機能解析2012

    • Author(s)
      中村惇・藤原滋樹
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcriptional regulatory mechanism of Hox1 gene in urochordates2012

    • Author(s)
      Kanda, M., Canestro, C. & Fujiwara, S
    • Organizer
      BSCB/BSDB/JSDB Joint Spring Meeting
    • Place of Presentation
      Coventry市,イギリス
    • Year and Date
      2012-04-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcriptional regulatory mechanism of Hox1 gene in urochordates.2012

    • Author(s)
      Kanda, M.
    • Organizer
      BSCB/BSDB/JSDB Joint Spring Meeting
    • Place of Presentation
      Univ. of Warwick(Coventry, UK)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 尾索動物におけるHox1遺伝子の転写調節2012

    • Author(s)
      神田美幸
    • Organizer
      ホヤ研究集会
    • Place of Presentation
      京都大学(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カタユウレイボヤにおけるグリコサミノグリカン硫酸転移酵素遺伝子の機能解析2012

    • Author(s)
      藤原滋樹
    • Organizer
      ホヤ研究集会
    • Place of Presentation
      京都大学(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カタユウレイボヤ胚におけるグリコサミノグリカン硫酸転移酵素の機能解析2012

    • Author(s)
      中村惇
    • Organizer
      日本動物学会 第83回大会
    • Place of Presentation
      大阪大学(豊中市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transcriptional regulatory mechanism of the Hox1 gene in Ciona intestinalis and Oikopleura dioica.2012

    • Author(s)
      Kanda, M.
    • Organizer
      Asia-Pacific Developmental Biology Conference
    • Place of Presentation
      Taipei Innovation City Convention Center(台北市,台湾)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ホヤの発生学2012

    • Author(s)
      藤原滋樹
    • Organizer
      フォーラム2012/衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋観光ホテル(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Devising a gene silencing method in Ciona intestinalis2011

    • Author(s)
      Nishioka, M. & Fujiwara, S
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Devising a gene silencing method in Ciona intestinalis2011

    • Author(s)
      Nishioka, M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミサキマメイタボヤの無性生殖におけるmyc遺伝子の発現と機能2011

    • Author(s)
      礒崎崇臣・森京子・川村和夫・藤原滋樹
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] ミサキマメイタボヤの無性生殖におけるmyc遺伝子の発現と機能2011

    • Author(s)
      藤原滋樹
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール(北海道)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 群体ホヤSymplegma virideの脳神経節の超微形態2011

    • Author(s)
      小山洋道
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール(北海道)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] カタユウレイボヤ胚の神経管形成におけるcdx遺伝子の役割2010

    • Author(s)
      川島大典・三田薫・藤原滋樹
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] カタユウレイボヤ胚の神経管形成におけるcux遺伝子の役割2010

    • Author(s)
      川島大典
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊索動物ホヤの表皮においてレチノイン酸 → Hox1カスケードはotic placode相同器官の形成に必須である2010

    • Author(s)
      笹倉靖徳・神田美幸・池田拓・堀江健生・河合成道・小椋陽介・吉田麗子・保住暁子・佐藤矩行・藤原滋樹
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊索動物ホヤの表皮においてレチノイン酸→Hox1カスケードはotic placode相同器官の形成に必須である2010

    • Author(s)
      笹倉靖徳
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] カタユウレイボヤ胚における動物半球特異的遺伝子のエンハンサー解析2010

    • Author(s)
      堀川陽輔・石田聡美・藤原滋樹
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] カタユウレイボヤ胚における動物半球特異的遺伝子のエンハンサー解析2010

    • Author(s)
      堀川陽輔
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホヤの発生学2010

    • Author(s)
      藤原滋樹・笹倉靖徳・神田美幸
    • Organizer
      フォーラム2012/衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋・招待講演
    • Year and Date
      2010-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] カタユウレイボヤのコンドロイチン硫酸転移酵素2010

    • Author(s)
      藤原滋樹
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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