Evolution of retinoic acid-dependent developmental regulatory system in chordates
| Project/Area Number |
22570214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKURA Yasunori 筑波大学, 生命環境科学研究科, 准教授 (10400649)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レチノイン酸 / Hox1 / 進化 / 遺伝子発現制御 / 脊索動物 / 遺伝子発現調節 |
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| Research Abstract |
We demonstrated that retinoic acid activates expression of the Hox1 gene in ascidian embryos. We also showed that retinoic acid and Hox1 contributed to organogenesis of ascidian larvae. The larvacean Oikopleura dioica does not have retinoic acid synthase and retinoic acid receptor in their genome, even though it is a close relative of ascidians. We found in the present study that both larvaceans and ascidians have retinoic acid-independent mechanism to activate transcription of Hox1. We hypothesized that the common ancestor of larvaceans and ascidians had both retinoic acid-dependent and independent pathways for the Hox1 activation. Larvaceans are thought to have survived the loss of retinoic acid-related genes, probably because they had two redundant pathways.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] The ANISEED database : digital representation, formalization, and elucidation of a chordate developmental program2010
Author(s)
O. Tassy, D. Dauga, F. Daian, D. Sobral, F. Robin, P. Khoueiry, D. Salgado, V Fox, D. Caillol, R. Schiappa, B. Laporte, A. Rios, G. Luxardi, T. Kusakabe, J. S. Joly, S. Darras, L. Christiaen, M. Contensin, H. Auger, C. Lamy, C. Hudson, U. Rothbacher, M. J. Gilchrist, K. W. Makabe, K. Hotta, S. Fujiwara, N. Satoh, Y Satou and P Lemaire
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Journal Title
Genome Res
Volume: 20
Issue: 10
Pages: 1459-1468
DOI
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Peer Reviewed
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[Presentation] ホヤの発生学2012
Author(s)
藤原滋樹
Organizer
フォーラム2012／衛生薬学・環境トキシコロジー
Place of Presentation
名古屋観光ホテル（名古屋市）
Related Report
Invited
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[Presentation] ホヤの発生学2010
Author(s)
藤原滋樹・笹倉靖徳・神田美幸
Organizer
フォーラム2012/衛生薬学・環境トキシコロジー
Place of Presentation
名古屋・招待講演
Year and Date
2010-10-26
Related Report
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