| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Through Dlx3-4 gene enhancer analysis, we found that (1) the core element of brachial arch enhancer I37-2 was conserved between mice and platypus, and branchial arch activity was acquired in placental mammal lineage. (2) I37-1 that shows limbs and hair follicles enhancer activities is quite ancient, conserved even in amphioxus. The core motif plays an important role in Dlx3 gene co-option in development of limbs and hair follicles
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