ANALYSIS OF EVOLUTIONARY MECHANISM OF DLX3 GENE CO-OPTION IN DEVELOPMENT OF NOVEL APPENDAGES OF VERTEBRATES
| Project/Area Number |
22570218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
SUMIYAMA Kenta 国立遺伝学研究所, 集団遺伝研究系, 助教 (00370114)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子進化 / シスエレメント進化 / 進化発生 / evo-devo / トランスジェニックマウス / 組織特異的エンハンサー / 転写制御 / Dlx遺伝子 / Tol2トランスポゼース |
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| Research Abstract |
Through Dlx3-4 gene enhancer analysis, we found that (1) the core element of brachial arch enhancer I37-2 was conserved between mice and platypus, and branchial arch activity was acquired in placental mammal lineage. (2) I37-1 that shows limbs and hair follicles enhancer activities is quite ancient, conserved even in amphioxus. The core motif plays an important role in Dlx3 gene co-option in development of limbs and hair follicles
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] "The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution."2012
Author(s)
Yuuta Moriyama, Toru Kawanishi Ryohei Nakamura Tatsuya Tsukahara, Kenta Sumiyama, Maximiliano L. Suster, Koichi Kawakami, Atsushi Toyoda, Asao Fujiyama, Yuuri Yasuoka, Yusuke Nagao, Etsuko Sawatari, Atsushi Shimizu, Yuko Wakamatsu Masahiko Hibi, Masanori Taira, Masataka Okabe, Kiyoshi Naruse, Hisashi Hashimoto, Atsuko Shimada, and Hiroyuki Takeda.
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Journal Title
Current Biology
Volume: 22(7)
Pages: 601-607
Related Report
Peer Reviewed
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[Journal Article] Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors2012
Author(s)
Kamioka, Y., Sumiyama, K., Mizuno, R., Sakia, Y., Hirata, E., Kiyokawa, E., Matsuda, M.
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Journal Title
Cell Structure and Function
Volume: 37
Issue: 1
Pages: 65-73
DOI
NAID
ISSN
0386-7196, 1347-3700
Related Report
Peer Reviewed
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[Journal Article] A Mammalian Conserved Element Derived from SINE Displays Enhancer Properties Recapitulating Satb2 Expression in Early-Born Callosal Projection Neurons2011
Author(s)
Tashiro K, Teissier A, Kobayashi N, Nakanishi A, Sasaki T, Yan K, Tarabykin V, Vigier L, Sumiyama K, Hirakawa M, Nishihara H, Pierani A, Okada N
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Journal Title
PLoS One
Volume: 6(12)
Issue: 12
Pages: e28497-e28497
DOI
Related Report
Peer Reviewed
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