Comparative genetical analysis among South American indigenous populations
| Project/Area Number |
22570231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
DANJO Inaho 独立行政法人理化学研究所, 細胞材料開発室, 協力研究員 (30415228)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 南米 / 先住民族 / 少数民族 / B-LCL / B細胞株 / ゲノム解析 / マイクロサテライト / アレイCGH / リソース |
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| Research Abstract |
We established B lymphoblastoid cell lines (EBV-B cell) from peripheral blood mononuclear cell stocks obtained from 550 South American indigenous individuals. We performed analysis of genetical relationships among tribes to make clear the migration rout of mongoloid populations from Eurasia to South America. Before starting genetical analysis, we checked the genomic stability of EBV-B cells during establishment and long-term culture periods, and showed that the cells retain stable genome structures by genetical studies. For the genetical analysis, samples were divided into 5 groups according to the geographical location, and then figured out the genetical features with forensic microsatellite markers. The results showed that each group retained smaller heterogeneity and specific allele frequency patterns for each microsatellite locus. These results suggest that Amerind populations are not so homogenous as a whole but can be divided into some genetically-diverse groups.
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Report
(4 results)
Research Products
(28 results)
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[Presentation] Genetic relationship among ethnic minority groups in South America from the viewpoint of autosomal and Y chromosomal STRs2011
Author(s)
Yamamoto, T., Ito, T., Gomyoda, T., Saijo, K., Danjoh, I., Nakamura, Y.
Organizer
International Congress of Human Genetics
Place of Presentation
Montreal, Canada
Year and Date
2011-10-14
Related Report
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[Presentation] Family selection study among DNA samples collected from an Amerindianethnic group (Wayuu) in northern Colombia2011
Author(s)
Yamamoto, T., Gomyoda, T., Ito, T., Saijo, K., Danjoh, I., Nakamura, Y.
Organizer
World Congress of the International Society for Forensic Genetics
Place of Presentation
Vienna, Austria(開催期間中ポスター掲示)
Related Report
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