| Project/Area Number |
22580064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TOMITA Takashi 国立感染症研究所, 昆虫医科学部, 室長 (20180169)
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| Co-Investigator(Kenkyū-buntansha) |
KASAI Shinji 国立感染症研究所, 昆虫医科学部, 主任研究官 (80332360)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMAGATA Osamu 国立感染症研究所, 昆虫医科学部, 研究員 (20435712)
ITOKAWA Kentaro 国立感染症研究所, 昆虫医科学部, 流動研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 害虫管理 / 生物的防除 / 殺虫剤抵抗性 / シトクロムP450 / マイクロアレイ / ネッタイイエカ / ピレスロイド / シス作用性突然変異 / 疾病媒介蚊 / 昆虫 / 遺伝学 / ゲノム / ピレスロイド系殺虫剤 / 遺伝子重複 |
|---|
| Research Abstract |
Cytochrome P450 genes genetically overexpressing and associated with each of larval and adult pyrethroid resistance in Culex quinquefasciatus were studied. We demonstrated that the overexpression of CYP9M10 due to cis-acting mutations is globally addressed to at least larval metabolic resistance to pyrethroids in this species and established a molecular genotyping method for identifying overexpressing CYP9M10 haplotypes.
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