| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Coenzyme A (CoA) functions as a carbon carrier. To clarify the regulation mechanism of the biosynthetic pathway of this important coenzyme, pantothenate kinase (CoaA) being the key enzyme was analyzed, and the following points were clarified. i) The enzymes which function in archaeal CoA biosynthetic pathway are not CoaAs which is commonly used in bacteria and eukaryotes but the intrinsic ones to archaea. ii) Two CoaA homologues in Bacillus subtilis have the enzyme activity, suggesting the possibility that both CoaAs are active in vivo.
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