| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Prospore membrane formation of budding yeast is studied as a model system for membrane biogenesis. In this study, we performed domain analysis on protein phosphatase type I targeting subunit, Gip1, and showed that distinct domains are required for its localization and function. We also showed that Spo71 and Spo73, peripheral membrane proteins required for prospore membrane formation, interact together on prospore membrane. Spo73 is a dysferlin domain-only protein. Our analysis on Spo73 provides some clues to elucidate the mechanism of a type of muscular dystrophy caused by mutations in dysferlin domain of dysferlin.
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