Iron homeostasis regulated by the CCAAT-binding complex in filamentous fungi.
| Project/Area Number |
22580080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Meijo University |
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Principal Investigator |
KATO Masashi 名城大学, 農学部, 教授 (70242849)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 麹菌 / 糸状菌 / 転写因子 / 鉄 / 恒常性 / CCAAT配列 / Aspergillus / アスペルギルス / 鉄の恒常性 / チロクロームc / Hap複合体 / HapX / DNaseIフットプリント法 / ゲルモビリティーシフトアッセイ / チトクロムc / DNA結合 |
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| Research Abstract |
Research on the HapX, a regulator involved in iron homeostasis in filamentous fungi led to some new findings, as follows. 1) Hap B/C/E complex-dependent specific bind- ing property of HapX to the promoters of genes coding iron containing proteins such as cytochrome c. has been elucidated. 2) In vivo analysis revealed the involvement of HapX in the iron homeostasis. 3) Truncated mutants of HapX and the truncated recombinant HapX were obtained to use for the future domain analysis of HapX.
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Report
(4 results)
Research Products
(14 results)
