Linkage between ribosome synthesis and vesicle transport
| Project/Area Number |
22580085
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
MIZUTA Keiko 広島大学, 大学院・生物圏科学研究科, 教授 (40166012)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUNATO Kouichi 広島大学, 大学院・生物圏科学研究科, 准教授 (30379854)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | リボソーム生合成 / 小胞輸送 / 核小体 / 核膜 / 酵母 / ストレス応答 / 出芽酵母 |
|---|
| Research Abstract |
To understand the linkage between ribosome biogenesis and other cellular systems, we investigated functions of trans-acting factors of ribosome biogenesis, Rrs1 and Ebp2. We found that Rrs1 and Ebp2 are localized at the periphery of the nuclear membrane and function on maintenance of telomereorganization. We also found that GSK3 protein kinases constitute the phosphorylation cascade in the signal transduction pathway due to secretory defects, where Rrs1 and Ebp2 are involved.
|
Report
(4 results)
Research Products
(66 results)
