| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
We explored the function of Rpd3/HDAC on the initiation and progression of meiosis/sporulation inthe budding yeast Saccharomyces cerevisiae, and found the followings. 1) HDAC activity of Rpd3 is repressed by the cooperation of multiple factors including at least Hac1 and Set3 upon induction of early-meiotic gene IME2. 2) Rpd3/HDAC positively regulates the expression of NDT80, encoding a key regulator of mid- and late-meiotic/spoluration genes, through facilitating the release of Sum1/Hst1 transcriptional repressor.
|
