| Project/Area Number |
22580087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOIRI Yuichro 大阪大学, 歯学研究科, 准教授 (50218286)
EBISU Shigeyuki 大阪大学, 歯学研究科 (50116000)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病原性細菌 / ゲノム再編 / Eikenella corrodens / 歯周病 / ファージ |
|---|
| Research Abstract |
We found that the genomic recombination occurs in periodontopathogenic bacterium, Eikenella corrodens, through phage infection. Moreover, we found that the genomic recombination leads to hypervirulation including the increase of lectin activity, biofilm formation, hemolytic activity, growth rate, and induction of inflammatory cytokine. We suggested that this hypervirulation might occur frequently in E. corrodens.
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