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Biological function and gene regulation of epididymal-specific carboxylesterase (CES4)

Research Project

Project/Area Number 22580100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionIwate University

Principal Investigator

YAMASHITA Tetsuro  岩手大学, 農学部, 准教授 (20202377)

Co-Investigator(Kenkyū-buntansha) MORIMATSU Masami  北海道大学, 遺伝子病制御研究所, 准教授 (70241370)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords精巣上体 / エステラーゼ / 酵素 / カルボキシルエステラーゼ / 遺伝子変異マウス / 巣上体 / KOマウス
Research Abstract

The biological function of an epididymal-specific carboxylesterase, CES4, was studied using Ces4 knock out mouse. The metabolome analysis of epididymal cell extracts revealed that the most of the glutathione was identified as oxidative form in the epididymis of KO mouse. The expression of oxidative stress-responsive heme oxygenase-1 (HO-1) was also increased in the KO mouse tissue. These data indicated that the epididymis of KO mouse was exposed by oxidative stress.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Characterisation of the carboxylesterase enzyme cauxin in the seminal fluid of the cat2011

    • Author(s)
      Miyazaki, M., Miyazaki, T., Toyonaga, M., Tsutsui, T., Taira, H., Yamashita, T. and Suzuki, A.
    • Journal Title

      The Veterinary Journal

      Volume: Vol. 190 Pages: 378-382

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterisation of the carboxylesterase enzyme cauxin in the seminal fluid of the cat2011

    • Author(s)
      Yamashita, T.
    • Journal Title

      Vet.J.

      Volume: (印刷中) Issue: 3 Pages: 378-382

    • DOI

      10.1016/j.tvjl.2010.11.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins2010

    • Author(s)
      Holmes, R., Wright, M., Laulederkind, S., Cox, L., Hosokawa, M., Imai, T., Ishibashi, S., Lehner, R., Miyazaki, M., Perkins, E., Potter, P., Redinbo, M., Robert, J., Satoh, T., Yamashita, T., Yan, B., Yokoi, T., Zechner, R. and Maltais, L. J.
    • Journal Title

      Mammalian Genome

      Volume: Vol. 21 Pages: 427-441

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recommended nomenclature for five mammaian carboxylesterase gene families human, mouse and rat genes and proteins.2010

    • Author(s)
      Roger S Holmes, Tetsurou Yamashita, et al.
    • Journal Title

      Mamm.Genome

      Volume: 21 Pages: 427-441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子欠損マウスを用いた精巣特異的カルボキシルエステラーゼ(CES4)の機能解析2012

    • Author(s)
      山下哲郎、金成瑞穂、松舘光人、宮崎雅雄、森松正美
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] ネコ尿タンパク質コーキシンと尿臭生成機構2012

    • Author(s)
      山下哲郎
    • Organizer
      日本獣医師会獣医学術学会年次大会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝子欠損マウスを用いた精巣特異的カルボキシルエステラーゼ(CES4)の機能解析2012

    • Author(s)
      山下哲郎
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ネコ尿タンパク質コーキシンと尿臭生成機構2011

    • Author(s)
      山下哲郎
    • Organizer
      平成23年度日本獣医師会獣医学術学会年次大会(招待講演)
    • Place of Presentation
      札幌コンベンションセンター (北海道)
    • Year and Date
      2011-02-03
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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