Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds
| Project/Area Number |
22580112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KIYOTA Hiromasa 東北大学, 大学院・農学研究科, 准教授 (30234397)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIDA Takafumi 東北大学, 大学院・農学研究科, 教授 (80312239)
USUI Takeo 筑波大学, 大学院・生命環境科学研究科, 准教授 (60281648)
KAWATANI Makoto 独立行政法人理化学研究所, 基幹研究所, 研究員 (50391925)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 抗生物質 / 植物毒素 / 海洋天然物 / ジャスモン酸 / タキサンジテルペノイド / 単離構造決定 / 全合成 / 構造活性相関 / 天然物 / 海洋物質 / テルペノイド / ポリケチド / ステロイド / 抗性物質 / cortistatins / Aspergillus puniceus / enacyloxins / JBIR-23 / maoecrystal V / echinopines |
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| Research Abstract |
Bioorganic research on biologically active natural products have been achieved. 1. Isolation and structure elucidation: the Canadian and Japanese yews, kaya tree, plant Achille, plant Inula, fungus Aspergillus. 2. Synthetic studies: echinopines (plant terpenoids), maoecrystal V (plant terpenoid), cortistatins (marine products) and EI-hybrids A-D, JBIR-23 (antibiotic), platensimycin (antibiotic),enacyloxins (antibiotics).
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] New 686-Taxanes Isolated from the Heartwood of Taxus cuspidata2012
Author(s)
K. Zhang, Y.-L., Z.-Y. Ni, M.-L. Zhang, Y.-F. Wang, M. Dong, Q.-W. Shi, C.-H. Huo, F. Sauriol, H. Kiyota, Y.-C. Gu, B. Cong
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Journal Title
Helv. Chim. Acta
Volume: 95巻
Issue: 9
Pages: 1566-1572
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel Taxa-4(20),12-diene and 2(3.RAR.20)Abeotaxane from Needles of Taxus canadensis2011
Author(s)
Z.-Y. Ni, Y.-B. Wu, M.-L. Zhang, Y.-F.Wang, M. Dong, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-C. Gu, H. Kiyota, and B. Cong
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 75
Issue: 9
Pages: 1698-1701
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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