| Project/Area Number |
22580115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIGAMI Ken 東京大学, 大学院・農学生命科学研究科, 准教授 (70292787)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機化学 / 天然物化学 / 立体化学 / 抗ピロリ菌 / セスキテルペン / ラジカル環化 / ラジカル環化反応 / Topsentolide / 抗腫瘍活性 / 有機合成化学 / 有機合成 / Ma jusculoic acid |
|---|
| Research Abstract |
Synthetic studies on bioactive natural products, which could be new drugs, were carried out in order to determine their stereochemistry. A new sesquiterpene, potent inhibitor of H. pylori growth, was efficiently synthesized as a racemate via tandem radical cyclization. The stereochemistry of topsentolide A was determined by synthesis of their possible stereoisomers, and cytotoxicity of the synthetic isomers was examined. About Majusculoic acid, a novel antifungal drug, new method to prepare the chiral building block was established.
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