| Project/Area Number |
22580117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Yokohama National University |
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Principal Investigator |
TAKEDA Minoru 横浜国立大学, 大学院・工学研究院, 准教授 (40247507)
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Kazuyoshi 横浜国立大学, 大学院・工学研究院, 教授 (40223458)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 天然物質化学 / Sphaerotilus natans / 鞘 / チオペプチドグリカン / 蛍光標識化 / 粘質性多糖 / 立体構造予測 / Leptothrix cholodnii / 鞘新生 / マンガン酸化 / マイクロカルチャー / 複合糖質 / 構造決定 / 多糖リアーゼ / Paenibacillus koleovorans |
|---|
| Research Abstract |
Terminal elongation of microtubes (sheaths) which are extracellulary produced by filamentous ion-oxidizing bacteria, Sphaerotilus natans and Leptothrix cholodnii, was confirmed by fluorescent microscopy. The sheaths were revealedto be commonly assembled from thiolic glycoconjugates composed of amphoteric glycan coreand dipeptide side chain containing glycine and cysteine. Considering their uniquechemical structures, the sheath-forming thiolic glycoconjugates were proposed to becollectively termed thiopeptidoglucan.
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