Comparative pharmacological studies on insect inhibitory neurotransmitter receptors

• Project/Area Number: 22580120
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Shimane University
• Principal Investigator: OZOE Yoshihisa 島根大学, 生物資源科学部, 教授 (80112118)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: グルタミン酸 / GABA / レセプター / 昆虫 / 神経伝達物質 / 薬理学

Research Abstract

Receptors that play an inhibitory synaptic transmission in insect nervous systems are an important target for agrochemicals. In the present study, the significance of inhibitory glutamate receptors (iGluRs) as an agrochemical target was examined by comparing their tissue distribution, function, and pharmacological properties with those of γ-aminobutyric acid receptors (GABARs) from a variety of viewpoints. The results indicated that GABARs have more potential than iGluRs.

Research Products

• [Journal Article] γ-Aminobutyrate- and glutamate-gated chloride channels as targets of insecticides (2013)
  • Author(s): Yoshihisa Ozoe
  • Journal Title: Advances in Insect Physiology Volume: 44 Pages: 211-286
  • DOI: 10.1016/b978-0-12-394389-7.00004-1
  • ISBN: 9780123943897
  • Peer Reviewed
• [Journal Article] Electrophysiological evidence for 4-isobutyl-3-isopropylbicyclo- phosphorothionate as a selective blocker of insect GABA-gated chloride channels (2013)
  • Author(s): Yuki Akiyoshi, Xiu-Lian Ju, Shogo Furutani, Kazuhiko Matsuda, Yoshihisa Ozoe
  • Journal Title: Bioorganic and Medicinal Chemistry Letters Volume: 23 Issue: 11 Pages: 3373-3376
  • DOI: 10.1016/j.bmcl.2013.03.085
  • Peer Reviewed
• [Journal Article] Competitive antago- nism of insect GABA receptors by iminopyridazine derivatives of GABA (2012)
  • Author(s): Mohammad Mostafizur Rahman, Yuki Akiyoshi, Shogo Furutani, Kazuhiko Matsuda, Kenjiro Furuta, Izumi Ikeda, Yoshihisa Ozoe
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 20 Issue: 19 Pages: 5957-5964
  • DOI: 10.1016/j.bmc.2012.07.049
  • Peer Reviewed
• [Presentation] イエバエ由来ヒスタミン作動性塩素イオンチャネルのアゴニストおよびアンタゴニストに対する応答 (2013)
  • Author(s): 野村和希,入江貴裕,喜多知,尾添富美代,尾添嘉久
  • Organizer: 日本農薬学会第38回大会
  • Place of Presentation: 筑波大学(つくば市)
  • Year and Date: 2013-03-15
• [Presentation] 4-Substituted 5-(4-piperidyl)-3-isothiazolols as competitive antagonists of insect GABA receptors (2013)
  • Author(s): Genyan Liu, Tomo Kita, Kazuki Nomura, Fumiyo Ozoe, Kenjiro Furuta, Izumi Ikeda, Yoshihisa Ozoe
  • Organizer: 日本農薬学会第38回大会
  • Place of Presentation: 筑波大学(つくば市)
  • Year and Date: 2013-03-15
• [Presentation] 4-Substituted 5-(4-piperidyl)-3-isothiazolols as competitive antagonists of insect GABA receptors (2013)
  • Author(s): Genyan Liu
  • Organizer: 日本農薬学会第38回大会
  • Place of Presentation: 筑波大学（つくば市）
• [Presentation] Synthesis of isothizolol antagonists that act on insect GABA receptors (2012)
  • Author(s): Genyan Liu, Kenjoro Furuta, Izumi Ikeda, Yoshihisa Ozoe
  • Organizer: 日本農芸化学会中四国支部大会(第34回講演会)
  • Place of Presentation: 山口大学(宇部市)
  • Year and Date: 2012-09-21
• [Presentation] ワモンゴキブリおよびラット神経細胞に発現するGABA およびグルタミン酸作動性クロルイオンチャネルに対する二環式リン酸エステルの選択的作用 (2012)
  • Author(s): 秋吉優季,古谷章吾,松田一彦,尾添嘉久
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学(岡山市)
  • Year and Date: 2012-05-15
• [Presentation] スプライスバリアントによって異なるイエバエ成虫グルタミン酸作動性クロルイオンチャネルの局在と機能 (2012)
  • Author(s): 喜多 知,尾添富美代,東 政明,尾添嘉久
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学(岡山市)
  • Year and Date: 2012-03-15
• [Presentation] Synthesis of 4-(6-imino-3-aryl/ heteroarylpyridazin-1-yl)butanoic acids and their antagonist activity toward insect GABA receptors (2012)
  • Author(s): Mohammad Mostafizur Rahman, Yuki Akiyoshi, Shogo Furutani, Kazuhiko Matsuda, Kenjiro Furuta, Yoshihisa Ozoe
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学(岡山市)
  • Year and Date: 2012-03-15
• [Presentation] スプライスバリアントによって異なるイエバエ成虫グルタミン酸作動性クロルイオンチャネルの局在と機能 (2012)
  • Author(s): 喜多知、尾添富美代、東政明、尾添嘉久
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学一般教育A棟
  • Year and Date: 2012-03-15
• [Presentation] Synthesis of 4-(6-immo-3-aryl/heteroarylpyridazin-1-yl)butanoic acids and their antagonist activity toward insect GABA receptors (2012)
  • Author(s): M.M.Rahman, Y.Akiyoshi, S.Furutani, K.Matsuda, K.Furuta, Y.Ozoe
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学一般教育A棟
  • Year and Date: 2012-03-15
• [Presentation] ワモンゴキブリおよびラット神経細胞に発現するGABAおよびグルタミン酸作動性クロルイオンチャネルに対する二環式リン酸エステルの選択的作用 (2012)
  • Author(s): 秋吉優季、古谷章吾、松田一彦、尾添嘉久
  • Organizer: 日本農薬学会第37回大会
  • Place of Presentation: 岡山大学一般教育A棟
  • Year and Date: 2012-03-15
• [Presentation] Synthesis of photo- reactive derivatives of ivermectin (2012)
  • Author(s): Toshinori Fuse, Izumi Ikeda, Mao Yamaguchi, Kazuhiko Matsuda, Yoshihisa Ozoe
  • Organizer: 5th Pan Pacific Conference on Pesticide Science
  • Place of Presentation: Beijing, China
• [Presentation] γ-Aminobutyric acid receptors: multiple potential sites for insecticidal actions (2012)
  • Author(s): Yoshihisa Ozoe
  • Organizer: 5th Pan Pacific Conference on Pesticide Science
  • Place of Presentation: Beijing, China
• [Presentation] Differential locali- zation of splice variants of a glutamate-gated chloride channel subunit in the housefly (2012)
  • Author(s): Tomo Kita, Masaaki Azuma, Fumiyo Ozoe, Yoshihisa Ozoe
  • Organizer: XXIV International Congress of Entomology
  • Place of Presentation: Daegu, Korea.
• [Presentation] Ligand-gated chloride channels: important sites for developing novel insecticides (2012)
  • Author(s): Yoshihisa Ozoe
  • Organizer: XXIV International Congress of Entomology
  • Place of Presentation: Daegu, Korea.
• [Presentation] Synthesis of isothizolol antagonists that act on insect GABA receptors (2012)
  • Author(s): Genyan Liu
  • Organizer: 日本農芸化学会中四国支部大会
  • Place of Presentation: 山口大学（宇部市）
• [Presentation] Synthesis of photoreactive derivatives of ivermectin (2012)
  • Author(s): Toshinori Fuse
  • Organizer: 5th Pan Pacific Conference on Pesticide Science
  • Place of Presentation: Beijing, China
• [Presentation] ワモンゴキブリ単離ニューロンに発現するリガンド作動性陰イオンチャネルのパッチクランプ解析 (2011)
  • Author(s): 秋吉優季,Mohammad Mostafizur Rahman,古谷章吾,松田一彦,古田賢次郎,尾添嘉久
  • Organizer: 平成23年度日本農芸化学会西日本支部・中四国支部合同大会
  • Place of Presentation: 宮崎大学(宮崎市)
  • Year and Date: 2011-09-17
• [Presentation] グルタミン酸作動性クロルイオンチャネルのイエバエ胸部神経系における局在解析 (2011)
  • Author(s): 喜多 知,尾添富美代,東 政明,尾添嘉久
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: (東日本大震災のため大会開催中止,要旨集発行,発表は成立)
  • Year and Date: 2011-03-05
• [Presentation] グルタミン酸作動性クロルイオンチャネルのイエバエ胸部神経系における局在解析 (2011)
  • Author(s): 喜多知、尾添富美代、東政明、尾添嘉久
  • Organizer: 日本農芸化学会2011年度大会講演旨集
  • Place of Presentation: 東日本大震災のため大会開催中止により口頭発表は中止。要旨集の発行をもって発表したという学会の判断。
  • Year and Date: 2011-03-05