Analysis of the mechanism of anti-diabetic effect by the isothiocyanate contained in brassica vegetables.
| Project/Area Number |
22580125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Iwate University |
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Principal Investigator |
ITO Yoshiaki 岩手大学, 農学部, 准教授 (50312517)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / イソチオシアネート / 脂肪細胞 / アディポサイトカイン / 機能性成分 / イソチオシアネート化合物 / シグナル伝達 / わさび / インスリン |
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| Research Abstract |
In this study, we investigated the mechanism of the antidiabetic effect of the isothiocyanate in brassica family vegetables. In mouse 3T3-L1 adipocytes, addition of isothiocyanate inhibits the fat accumulation and protects from the insulin resistance induced by oxidative stress. Moreover, the intake of the Japanese horseradish powder which removed the pungent and major isothiocyanate, allyl isothiocyanate, alleviated hyperglycemia in diabetic KK-Ay mice. The similar effect was also observed in diabetic mice fed a diet with another isothiocyanate in watercress. These results suggest a possibility that several isothiocyanates and food stuffs containing isothiocyanates have anti-diabetic effect.
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Report
(4 results)
Research Products
(15 results)
