| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
In this study, we investigated the mechanism of the antidiabetic effect of the isothiocyanate in brassica family vegetables. In mouse 3T3-L1 adipocytes, addition of isothiocyanate inhibits the fat accumulation and protects from the insulin resistance induced by oxidative stress. Moreover, the intake of the Japanese horseradish powder which removed the pungent and major isothiocyanate, allyl isothiocyanate, alleviated hyperglycemia in diabetic KK-Ay mice. The similar effect was also observed in diabetic mice fed a diet with another isothiocyanate in watercress. These results suggest a possibility that several isothiocyanates and food stuffs containing isothiocyanates have anti-diabetic effect.
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