Polyphenols of functional foods as materialseffectiveon tumor cells

• Project/Area Number: 22580128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Okayama University
• Principal Investigator: HATANO Tsutomu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50127578)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Yasuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00163387) ; SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 (50138484)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 機能性食品 / ポリフェノール / タンニン / 抗腫瘍作用 / 植物組織培養 / 人工タンニン / ギョリュウ科 / バラ科 / 食品 / 植物 / 機能性成分 / 培養がん細胞 / 口腔がん / ギョリュウ科植物 / 未利用植物資源 / 高分子ポリフェノール / 物質生産 / 口腔がん細胞

Research Abstract

Tannins of several plant resources including those used for functional foods were investigated, and various tannins including new ones were isolated from a tamaricaceous plant grown in Egypt. Several tannins among them showed selective cytotoxicity against human oral squamous cell carcinoma (OSCC) cell lines. Those tannins were produced in cultured tissues induced from Tamarix tetrandra successfully. Artificial tannins based on oligosaccharide cores were newly synthesized, and they also showed selective cytotoxicity against OSCC cell lines.

Research Products

• [Journal Article] New Oxidation Products from (-)-Epigallocatechin Gallate in Neutral Solution (2011)
  • Author(s): Ohyabu T, Taniguchi S, Ito H, Hatano T
  • Journal Title: Heterocycles Volume: Vol. 82 Pages: 1685-1692
  • Peer Reviewed
• [Journal Article] Hydrolyzable Tannins of Tamaricaceous Plants. IV: Micropropagation and Ellagitannin Production in Shoot Cultures of Tamarix tetrandra (2011)
  • Author(s): Orabi MA, Taniguchi S, Terabayashi S, Hatano T
  • Journal Title: Phytochemistry Volume: Vol. 72 Pages: 1978-1989
  • Peer Reviewed
• [Journal Article] Hydrolyzable tannins of tamaricaceous plants. IV : Micropropagation and ellagitannin production in shoot cultures of Tamarix tetrandra (2011)
  • Author(s): Orabi MA, Taniguchi S, Terabayashi S, Hatano T
  • Journal Title: Phytochemistry Volume: 72 Issue: 16 Pages: 1978-1989
  • DOI: 10.1016/j.phytochem.2011.07.011
  • Peer Reviewed
• [Journal Article] New Oxidation Products from (-)-Epigallocatechin Gallate in Neutral Solution (2011)
  • Author(s): Ohyabu, T
  • Journal Title: Heterocycles Volume: 82 Pages: 1685-1692
  • Peer Reviewed
• [Journal Article] Hydrolyzable Tannins of Tamaricaceous Plants. III. Hellinoyl- and Macrocyclic-type Ellagitannins from Tamarix nilotica (2010)
  • Author(s): Orabi MAA, Taniguchi S, Yoshimura M, Yoshida T, Kishino K, Sakagami H, Hatano T
  • Journal Title: Journal of Natural Products Volume: Vol. 73 Pages: 870-879
  • Peer Reviewed
• [Journal Article] Hydrolyzable Tannins of Tamaricaceous Plants. III. Hellinoyl- and Macrocyclic-Type Ellagitannins from Tamarix nilotica (2010)
  • Author(s): Orabi, M.A.A.
  • Journal Title: J.Nat.Prod. Volume: 73 Pages: 870-879
  • Peer Reviewed
• [Presentation] 薬用植物および食品中のタンニン及び関連ポリフェノールによるAeromonas科およびVibrio科細菌に対する影響 (2012)
  • Author(s): 波多野 力他
  • Organizer: 第19回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 大阪大学会館(大阪府豊中市)
• [Presentation] 薬用植物および食品中のタンニン及び関連ポリフェノールによるAeromonas科およびVibrio科細菌に対する影響 (2012)
  • Author(s): 波多野 力
  • Organizer: 第１９回天然薬物の開発と応用シンポジウム
  • Place of Presentation: 大阪
• [Presentation] 抗腫瘍作用を有する人工タンニンの合成 (2011)
  • Author(s): 小川卓也
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: (講演要旨誌上)
  • Year and Date: 2011-03-05
• [Presentation] 抗腫瘍作用を有する人工タンニンの合成 (2010)
  • Author(s): 竹内 靖雄他
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 震災のため講演要旨集誌上開催とされた
  • Year and Date: 2010-03-05
• [Presentation] Tannins of Tamarix Plants: Structures of New Ellagitannins, Cytotoxicity of Tamarix Tannins, and Accumulation of Tannins in Cultures Shoots (2010)
  • Author(s): Hatano T他
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: 静岡県コンベンションアーツセンター(グランシップ)(静岡市)
• [Presentation] Tannins of Tamarix Plants : Structures of New Ellagitannins, Cytotoxicity of Tamarix Tannins, and Accumulation of Tannins in Cultures Shoots (2010)
  • Author(s): Orabi, M.A.A.
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: グランシップ(静岡市)
• [Book] A Compendium of Essays on Alternative Therapy (edited by Bhattacharya A) (Chapter 13, Functional Analysis of Natural Polyphenols and Saponins as Alternative Medicines) (2012)
  • Author(s): Sakagami H, Kushida T, Makino T, Hatano T, Shirataki Y, Matsuta T, Matsuo Y, Mimaki Y, In Tech (Rijeka, Croatia)
• [Book] ポリフェノール:薬用植物および食品の機能性成分 (波多野 力監修)(序章 ポリフェノールの化学構造の多様性および第9章 高分子ポリフェノールの構造とタンパク質分子との相互作用) (2012)
  • Author(s): 波多野 力
  • Publisher: シーエムシー出版
• [Book] ポリフェノール:薬用植物および食品の機能性成分（序章・ポリフェノールの化学構造の多様性および第９章・高分子ポリフェノールの構造とタンパク質分子との相互作用） (2012)
  • Author(s): 波多野 力
  • Total Pages: 26
  • Publisher: シーエムシー出版
• [Book] A Compendium of Essays on Alternative Therapy (edited by Arup Bhattacharya). Chapter 13. Functional analysis of natural polyphenols and saponins as alternative medicines (pp.269-302) (2012)
  • Author(s): Sakagami H, Kushida T, Makino T, Hatano T, Shirataki Y, Matsuta T, Matsuo Y, Mimaki Y
  • Publisher: InTech (Rijeka, Croatia)
• [Patent(Industrial Property Rights)] 新規タンニン誘導体 (2011)
  • Inventor(s): 波多野 力、竹内 靖雄、坂上 宏
  • Industrial Property Rights Holder: 波多野 力、竹内 靖雄、坂上 宏
  • Filing Date: 2011-01-28
• [Patent(Industrial Property Rights)] 新規タンニン誘導体 (2011)
  • Inventor(s): 波多野力、竹内靖雄、坂上宏
  • Industrial Property Rights Holder: 波多野力、竹内靖雄、坂上宏
  • Industrial Property Number: 2011-016195
  • Filing Date: 2011-01-28