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Study on the mechanism of multi-function of food-derived anti-angiogenic compounds and their application

Research Project

Project/Area Number 22580130
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionHiroshima University

Principal Investigator

MATSUBARA Kiminori  広島大学, 大学院・教育学研究科, 准教授 (90254565)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords血管新生 / 多機能性 / 血管内皮細胞 / 神経細胞 / 脳 / オートファジー / 食品機能 / 老化 / カルノシン酸 / 神経変成疾患 / 食品機能成分 / 細胞保護作用 / 酸化ストレス / 神経毒1
Research Abstract

It has been demonstrated that antiangiogenic activity is a common biological activity of food-derived bioactive compounds that are useful for human health. In this study, the molecular mechanisms how such compounds exert various useful effects on human health were investigated. Consequently, it has been revealed that the compounds affect gene expression, cell signaling pathways, and autophagy. Oral administration of the compound prevents brain function in animal aging model.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (12 results)

  • [Journal Article] Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves2012

    • Author(s)
      Tomoko Kayashima, Kiminori Matsubara
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76 Pages: 115-119

    • NAID

      10030398694

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管新生抑制作用を有する食品機能成分の多機能性2012

    • Author(s)
      松原主典
    • Journal Title

      化学工業

      Volume: 63 Pages: 1-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] ローズマリー成分カルノシン酸の血管新生抑制作用と皮膚保護作用2012

    • Author(s)
      松原主典
    • Journal Title

      AROMA RESEARCH

      Volume: 13 Pages: 319-322

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic Effect of Carnosic Acid and Carnosol, Neuroprotective Compounds in Rosemary Leaves2012

    • Author(s)
      Kayashima, T., Matsubara, K.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 1 Pages: 115-119

    • DOI

      10.1271/bbb.110584

    • NAID

      10030398694

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ローズマリー成分カルノシン酸の血管新生抑制作用と皮膚保護作用2012

    • Author(s)
      松原主典
    • Journal Title

      AROM RESEARCH

      Volume: 13 Pages: 319-322

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor2010

    • Author(s)
      Kayashima, T., et al.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 18 Pages: 6305-6309

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] カルノシン酸の神経細胞保護作用機構と経口摂取による効果の検討2013

    • Author(s)
      柴田紗知,丸橋里紗, 萱島知子, 松原主典
    • Organizer
      日本家政学会第65回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] カルノシン酸及びスルフォラファンの神経細胞保護作用機序2013

    • Author(s)
      柴田紗知,萱島知子, 松原主典
    • Organizer
      日本農芸化学会 2013 年度(平成 25 年度)大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] カルノシン酸及びスルフォラファンの神経細胞保護作用機序2013

    • Author(s)
      柴田紗知、萱島知子、松原主典
    • Organizer
      日本農芸化学会 2013年度(平成25年度)大会
    • Place of Presentation
      仙台(宮城)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カルノシン酸の神経細胞保護作用機構と経口摂取による効果の検討2013

    • Author(s)
      柴田紗知、丸橋里紗、萱島知子、松原主典
    • Organizer
      日本家政学会 第65回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海藻カロテノイドによる血管新生抑制作用の分子機構2012

    • Author(s)
      Ganesan, P., 松原主典, 菅原達也, 平田孝
    • Organizer
      に本農芸化学会2012年度(平成24年度)大会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] ローズマリー成分カルノシン酸の神経細胞保護作用とその作用機序2012

    • Author(s)
      柴田紗知,萱島知子, 松原主典
    • Organizer
      日本農芸化学会中四国支部第34回講演会(支部大会)
    • Place of Presentation
      宇部
    • Related Report
      2012 Final Research Report
  • [Presentation] ローズマリー成分カルノシン酸による神経細胞保護作用2012

    • Author(s)
      柴田紗知,松原主典, 萱島知子
    • Organizer
      日本家政学会第64回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 海藻カロテノイドによる血管新生抑制作用の分子機構2012

    • Author(s)
      Ganesan, P.,松原主典, 菅原達也, 平田孝
    • Organizer
      日本農芸化学会 2012 年度(平成 24 年度)大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] ローズマリー成分カルノシン酸による神経細胞保護作用2012

    • Author(s)
      柴田紗知、松原主典、萱島知子
    • Organizer
      日本家政学会 第64回大会
    • Place of Presentation
      大阪(大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ローズマリー成分カルノシン酸の神経細胞保護作用とその作用機序2012

    • Author(s)
      柴田紗知、萱島知子、松原主典
    • Organizer
      日本農芸化学会中四国支部 第34回講演会(支部大会)
    • Place of Presentation
      宇部(山口)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves2011

    • Author(s)
      Kayashima, T., Shibata, S., Matsubara, K.
    • Organizer
      International Society for Nutraceuticals & Functional Foods 2011 Annual Conference
    • Place of Presentation
      札幌市
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antiangiogenic effect of carnosic acid and carnosol2011

    • Author(s)
      Kayashima Tomoko, Sachi Shibata, Kiminori Matsubara
    • Organizer
      neuroprotective compounds in rosemary leaves
    • Place of Presentation
      Sapporo (Japan)
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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