Exploring natural resources-derived compounds that suppress up-regulation of histamine H1 receptor gene expression as a diseases-sensitive gene
| Project/Area Number |
22580132
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
MIZUGUCHI Hiroyuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (40247838)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ヒスタミンH1受容体遺伝子 / アレルギー疾患感受性遺伝子 / 転写調節 / 天然医薬 / 天然物医薬 / ヒスタミンH1受容体 / セルフメディケーション |
|---|
| Research Abstract |
We explored natural resources-derived compounds that suppress histamine H1R gene expression and identified (-)-maackiaain as one of the active compounds. H1R gene expression was mediated through the PKCδ/ERK/PARP-1 signaling pathway and translocation of PKCδto the Golgi in response to PMA stimulation was found to be very important for H1R gene expression in HeLa cells. We identified Hsp90 as a target protein for (-)-maackiain. (-)-Maackiain inhibited binding of PKCδto Hsp90 and suppressed PKCδtranslocation to the Golgi, resulting the suppression of H1R gene expression. Hsp90 inhibitors suppressed the up-regulation of H1R gene expression and alleviated allergic symptoms in allergy model rats.
|
Report
(4 results)
Research Products
(83 results)
-
-
[Journal Article] Quercetin inhibits transcriptional up-regulation of histamine H(1) receptor via suppressing protein kinase C-δ/ extracellular signal- regulated kinase/ poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells2013
Author(s)
Hattori M, Mizuguchi H, Baba Y, Ono S, Nakano T, Zhang Q, Sasaki Y, Kobayashi M, Kitamura Y, Takeda N, Fukui H
-
Journal Title
Int Immunopharmacol
Volume: 15
Pages: 232-239
Related Report
Peer Reviewed
-
-
-
[Journal Article] PMA-induced dissociation of Ku86 from the promoter causes transcriptional up- regulation of histamine H(1) receptor2012
Author(s)
Mizuguchi H, Miyagi K, Terao T, Sakamoto N, Yamawaki Y, Adachi T, Ono S, Sasaki Y, Yoshimura Y, Kitamura Y, Takeda N, Fukui H
-
Journal Title
Sci Rep
Volume: 2
Issue: 1
Pages: 916-916
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
