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Mechanism of inhibitory activityof lipolysis by basic polypeptide.

Research Project

Project/Area Number 22580134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionEhime University

Principal Investigator

TSUJITA Takahiro  愛媛大学, 総合科学研究支援センター, 准教授 (60112265)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords栄養学 / 脂質 / 食品 / 肥満 / 塩基性ペプチド / リパーゼ / 抗肥満作用 / ポリリジン / プロタミン / 膵リパーゼ
Research Abstract

We discovered that the basic biopolymers such as basic polypeptide was strong inhibitors of pancreatic lipase reaction. They might interact with substrate surface and inhibit lipolysis and have anti-obesity function that act by inhibiting intestinal absorption of dietary fat. The lipase inhibition increased with the degree of polymerization of basic amino acids up to 10. The basic polypeptide might be strong lipase inhibitors and free from side effect. Therefore, they could be considered a potential new tool to prevent obesity.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] Purification and characterization of polyphenol from chestnut astringent skin.2011

    • Author(s)
      Takahiro Tsujita, Misato Yamada, Takeshi Takaku, Tomoyoshi Shintani, Kanae Teramoto and Takefumi Sato
    • Journal Title

      J. Agric Food Chem

      Volume: 59巻 Issue: 16 Pages: 8646-8654

    • DOI

      10.1021/jf201679q

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ピーナツ渋皮抽出物の血糖降下メカニズム2012

    • Author(s)
      辻田隆広、高久武司
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 栗渋皮ポリフェノールのリパーゼ阻害作用2012

    • Author(s)
      辻田隆広、高久武司
    • Organizer
      日本農芸化学会2012 年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ナッツ渋皮ポリフェノールの生理機能について2011

    • Author(s)
      辻田隆広、高久武司
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 栗渋皮ポリフェノールの精製と機能解析2011

    • Author(s)
      辻田隆広、高久武司、新谷智吉
    • Organizer
      日本農芸化学会 2011 年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 栗渋皮ポリフェノールの精製と機能解析2011

    • Author(s)
      辻田隆広、高久武司、新谷智吉
    • Organizer
      日本農芸化学会2011度大会
    • Place of Presentation
      京都市
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] キトサンの膵リパーゼ阻害機序及び抗肥満作用について2010

    • Author(s)
      辻田隆広、山田美里、高久武司
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] キトサンの膵リパーゼ阻害機序及び抗肥満作用について2010

    • Author(s)
      辻田隆広、山田美里、高久武司
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ペクチンの脂肪吸収抑制作用機序の解析2010

    • Author(s)
      辻田隆広、山田美里、高久武司、石井靖子、枝重有祐
    • Organizer
      日本農芸化学会 2010 年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] アーモンド渋皮ポリフェノールの精製と性質について

    • Author(s)
      辻田隆廣
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 落花生渋皮ポリフェノールの精製とその性質

    • Author(s)
      辻田隆廣
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] ピーナツ渋皮抽出物の血糖降下メカニズム

    • Author(s)
      辻田隆廣
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 栗渋皮ポリフェノールの精製と機能解析

    • Author(s)
      辻田隆広、高久武司、新谷智吉
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      (震災のため誌上発表)(誌上発表)
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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