| Project/Area Number |
22580136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
MIZUNOYA Wataru 九州大学, 大学院・農学研究院, 助教 (20404056)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEUCHI Yoshihide 九州大学, 大学院・農学研究院, 教授 (90168112)
TATSUMI Ryuichi 九州大学, 大学院・農学研究院, 准教授 (40250493)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 栄養化学 / 骨格筋 / 筋線維型 / 脂肪酸 / 筋線維タイプ / ラット / PPARδ / ミオシン重鎖 / 単離筋線維 / エイコサペンタエン酸 / PPARσ / 衛星細胞 |
|---|
| Research Abstract |
Skeletal muscle fibers are classified as slow-type and fast-type based on color, metabolism and contractile properties. Here, we tested whether food component could affect muscle fiber type. Here, we succeeded in establishing a rat muscle fiber-culture assay, in which fibersexpress mature myofibrillar proteins. Then, we revealed that PDK4 and UCP3 mRNAs, known target genes of PPARδand abundant in slow-type fibers, were up-regulated when eicosapentaenoic acid (EPA), abundant in fish oil, was added to fiber cultures for 24 hours.
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