| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
To synthesize flavonoid-O-sulfates and flavonoid-O-glucuronides, flavanone, flavone, flavonol and isoflavone were reacted with a sulfur trioxide pyridine and an acetobromo-glucuronide methylester. The products were analyzed by HPLC and purified by Toyopearl HW40 column chromatography. Chemical structures of the products wereidentified by LCMS and 1H-NMR. The yields of flavonoid-sulfates were good but that of glucuronides were poor. The antioxidant activity and ACE inhibiting activity were decreased by sulfation and glucuronidation of flavonoid aglycones.
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