Development of a method for the synthesis of flavonoid conjugates andevaluation of their physiological functionalities.
| Project/Area Number |
22580139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 建夫 , 名誉教授 (80005652)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | フラボノイド抱合体 / 硫酸抱合体 / グルクロン酸抱合体 / 抱合体合成 / ポリフェノール / 抗酸化性 / ACE 阻害 / ACE阻害活性 / 食品機能性 / フラボノイド / フラボノイドグルクロン酸抱合体 / フラボノイド硫酸抱合体 |
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| Research Abstract |
To synthesize flavonoid-O-sulfates and flavonoid-O-glucuronides, flavanone, flavone, flavonol and isoflavone were reacted with a sulfur trioxide pyridine and an acetobromo-glucuronide methylester. The products were analyzed by HPLC and purified by Toyopearl HW40 column chromatography. Chemical structures of the products wereidentified by LCMS and 1H-NMR. The yields of flavonoid-sulfates were good but that of glucuronides were poor. The antioxidant activity and ACE inhibiting activity were decreased by sulfation and glucuronidation of flavonoid aglycones.
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Report
(4 results)
Research Products
(8 results)
