• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a method for the synthesis of flavonoid conjugates andevaluation of their physiological functionalities.

Research Project

Project/Area Number 22580139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionMiyagi University

Principal Investigator

TSUSHIDA Tojiro  宮城大学, 食産業学部, 教授 (00353920)

Co-Investigator(Kenkyū-buntansha) 鈴木 建夫  , 名誉教授 (80005652)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsフラボノイド抱合体 / 硫酸抱合体 / グルクロン酸抱合体 / 抱合体合成 / ポリフェノール / 抗酸化性 / ACE 阻害 / ACE阻害活性 / 食品機能性 / フラボノイド / フラボノイドグルクロン酸抱合体 / フラボノイド硫酸抱合体
Research Abstract

To synthesize flavonoid-O-sulfates and flavonoid-O-glucuronides, flavanone, flavone, flavonol and isoflavone were reacted with a sulfur trioxide pyridine and an acetobromo-glucuronide methylester. The products were analyzed by HPLC and purified by Toyopearl HW40 column chromatography. Chemical structures of the products wereidentified by LCMS and 1H-NMR. The yields of flavonoid-sulfates were good but that of glucuronides were poor. The antioxidant activity and ACE inhibiting activity were decreased by sulfation and glucuronidation of flavonoid aglycones.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] 沖縄伝統野菜のカロテノイドの定量2011

    • Author(s)
      前田剛希、伊波聡、津志田藤二郎
    • Journal Title

      日本食品科学工学会

      Volume: Vol58、No.3 Pages: 105-112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗酸化能測定法である H-ORAC 法の室間共同試験2010

    • Author(s)
      渡辺純、沖智之、竹林純、山崎浩二、津志田藤二郎
    • Journal Title

      日本食品科学工学会誌

      Volume: Vol.57、No12 Pages: 525-531

    • NAID

      10027498323

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 標準となる抗酸化能測定法の選定と抗酸化指標の表示について2010

    • Author(s)
      津志田藤二郎
    • Journal Title

      食品と開発

      Volume: 45巻、No.6 Pages: 4-6

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] 抗酸化能測定法であるH-ORAC法の室間共同試験2010

    • Author(s)
      渡辺、沖、竹林、山崎、津志田
    • Journal Title

      日本食品科学工学会誌

      Volume: 57 Pages: 525-531

    • NAID

      10027498323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] フラボノイド抱合体の有機合成に関する研究-特に硫酸抱合体について2012

    • Author(s)
      佐伯太郎、津志田藤二郎
    • Organizer
      日本フードファクター学会
    • Place of Presentation
      静岡県男女共同参画センター
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] フラボノイド抱合体の有機合成に関する研究 特に硫酸抱合体について2012

    • Author(s)
      佐伯太朗、津志田藤二郎
    • Organizer
      第17回日本フードファクター学会
    • Place of Presentation
      静岡県男女共同参画センター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of Unified method for Measuring Antioxidant Capacity to Use for Food Labeling2011

    • Author(s)
      T.Tsushida, J.Watanabe
    • Organizer
      ICoff2011 Taipei
    • Place of Presentation
      台北国際コンベンションセンター
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Unified Method for Measureing Antioxidant Capacity to Use for Food Labeling2011

    • Author(s)
      Tojiro Tsushida 、 Jun Watanabe
    • Organizer
      ICoff2011 Taipei
    • Place of Presentation
      台北国際コンベンションセンター
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi