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Antioxidant induced decrement of β-amyloid deposits by phase contrast X-ray technique

Research Project

Project/Area Number 22580145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKitasato University

Principal Investigator

MARUYAMA Hiroko  北里大学, 医療衛生学部, 准教授 (50129269)

Co-Investigator(Kenkyū-buntansha) TAKEDA Tohoru  北里大学, 医療衛生学部, 教授 (10197311)
KAWAKAMI Fumitaka  北里大学, 医療衛生学部, 助教 (50511896)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアルツハイマー病 / βアミロイド蛋白質 / タウ蛋白質 / クルクミン / タウ蛋白質リン酸化 / 位相 X 線画像 / Tau蛋白質 / Tau蛋白質リン酸化 / 位相X線画像 / 抗酸化物質 / 脳神経疾患 / 免疫組織染色 / βアミロイドタンパク質 / タウタンパク質 / アルツハイマー
Research Abstract

Inhibition of Alzheimer’s disease (AD) by antioxidant curcumin has attracted the attention of scientists. Curcumin effect on Alzheimer’s disease was examined for short-term memory impairment, reduced amyloid deposits and tau hyperphoshorylation using AD model mouse. Our study demonstrates that curcumin is not only inhibited Aβ deposition but also to prevent Tau phosphorylation. Thus, curcumin might be considered to prevent the AD.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Ethanol fixed brain imaging by phase-contrast X-ray technique. Journal of Physics2013

    • Author(s)
      Tohoru Takeda, Thet-Thet-Lwin, Takuya Kunii, Ryota Sirai, Takahito Ohizumi, Hiroko Maruyama, Kazuyuki Hyodo, Akio Yoneyama, and Kazuhiro Ueda
    • Journal Title

      Conference Series

      Volume: 425 Issue: 2 Pages: 1-4

    • DOI

      10.1088/1742-6596/425/2/022004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] アルツハイマーモデルマウスにおけるクルクミンの発症抑制効果2012

    • Author(s)
      大泉孝仁、丸山弘子、國井琢矢、白井亮多、秋田久直、 川上文貴、大部誠、 武田徹
    • Organizer
      第25回北里大学バイオサイエンスフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2012-08-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] クルクミンによるβアミロイド蛋白質産生抑制効果の基礎的検討2012

    • Author(s)
      大泉孝仁、丸山弘子、國井琢矢、白井亮多、秋田久直、 川上文貴、大部誠、 武田徹
    • Organizer
      第66回日本栄養・食糧学会講演要旨集
    • Place of Presentation
      仙台
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] クルクミンによるβアミロイド蛋白質産生抑制効果の基礎的検討2012

    • Author(s)
      大泉孝仁、丸山弘子、國井琢矢、白井亮多、秋田久直、川上文貴、大部誠、武田徹
    • Organizer
      第66回日本栄養・食糧学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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