Antioxidant induced decrement of β-amyloid deposits by phase contrast X-ray technique
| Project/Area Number |
22580145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Tohoru 北里大学, 医療衛生学部, 教授 (10197311)
KAWAKAMI Fumitaka 北里大学, 医療衛生学部, 助教 (50511896)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アルツハイマー病 / βアミロイド蛋白質 / タウ蛋白質 / クルクミン / タウ蛋白質リン酸化 / 位相 X 線画像 / Tau蛋白質 / Tau蛋白質リン酸化 / 位相X線画像 / 抗酸化物質 / 脳神経疾患 / 免疫組織染色 / βアミロイドタンパク質 / タウタンパク質 / アルツハイマー |
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| Research Abstract |
Inhibition of Alzheimer’s disease (AD) by antioxidant curcumin has attracted the attention of scientists. Curcumin effect on Alzheimer’s disease was examined for short-term memory impairment, reduced amyloid deposits and tau hyperphoshorylation using AD model mouse. Our study demonstrates that curcumin is not only inhibited Aβ deposition but also to prevent Tau phosphorylation. Thus, curcumin might be considered to prevent the AD.
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Report
(4 results)
Research Products
(4 results)
