Elucidation of anti-obesity effects of hop procyanidins or its depolymerized compounds
Project/Area Number |
22580148
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Meiji University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | ホップ / ポリフェノール / プロシアニジン / 肥満 / 糖尿病 / 脂質代謝 / ラット / 抗酸化 / 吸収 / アディポサイトカイ / コレステロール |
Research Abstract |
Hop (Humulus lupulus L.) pomace contains procyanidin-rich polyphenols, large oligomeric compounds of catechin. Effect of high dose (1%) of dietary hop pomace polyphenols (HP) in OLETF rats, an animal model of type 2 diabetes, was studied. The rats fed HP tended to have a lower body weight and reduced white adipose tissue weight than the rats fed a control diet. Triglyceride levels in both plasma and liver tended to be lower in the HP fed group than in the control group. Thus, dietary HP may exert anti-obesity effect through the ameliorative function on hepatic fatty acid metabolism and inhibition of fat and glucose absorption from intestine.
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Report
(4 results)
Research Products
(35 results)