Effects of reactive oxygen species and lipid peroxide on antibodies production

Research Project

Project/Area Number	22580151
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Food science
Research Institution	Kyushu Sangyo University
Principal Investigator	TAKASUGI Mikako 九州産業大学, 工学部, 准教授 (60305802)
Co-Investigator(Kenkyū-buntansha)	ARAI Hirofumi 北見工業大, 工学部, 准教授 (70295848) YAMADA Koji 九州大学, 農学研究科, 教授 (60158186)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	アレルギー / 活性酸素 / 脂質 / 酸化 / HNE / IgA / IgE
Research Abstract	4-hydroxy-2-nonenal, a secondary product generated bydecomposition of lipid hydroperoxides, suppressed IgA production from KHM-1B in adose-dependent manner. Tyrosine phosphorylations of signal molecules around 64 kDawere inhibited by 4-hydroxy-2-nonenal in twelve-hour culture. These data suggest that4-hudroxy-2-nonenal might facilitate allergy reaction by suppression of IgA production.

Report

(4 results)