| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Hypoxia is a key factor in tumorigenesis. Hypoxia induces theexpression of hypoxia-inducible factor (HIF), which is a transcriptional factor forhypoxia-responsive genes. HIF is a heterodimeric protein composed of HIF-α and HIF-β.The α subunit (HIF-2α) is limiting factor for HIF expression because HIF-2α is stablyexpressed in hypoxia, but not in normoxia. In the present study, we demonstrate thatKLHL20 enhances the expression of HIF-2α and that HIF-2α down-regulates theexpression of estrogen receptor α in normoxia. Based on these results, we constructed acell-based bioassay system for hypoxic response and determined anti-hypoxic activity offood components.
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