| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Although the lipid molecular species of inside-and-outside layer in biomembrane phospholipid bilayer differ extremely, influence of the asymmetric distribution for lipid peroxidation in the phospholipid bilayer is disregarded in most of studies. In the present study, it was observed that cholesterol showed the antioxidation ability more than equivalent compared with vitamin E at physiological concentrations, and not only the asymmetry of phospholipid bilayer but also the molecular shape of coexistence phospholipid affected the antioxidation ability of cholesterol. However, the both results of in vitro system and in vivo system were not in agreement.
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