• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the taste signalosome involved from taste reception to taste signal generation to understand taste interactions

Research Project

Project/Area Number 22580154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

KUSAKABE Yuko  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (90353937)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食品機能 / 味覚 / 情報伝達 / 複合体 / シグナロソーム / 味細胞 / イオン動態 / カルシウムイメージング / 免疫沈降法
Research Abstract

We conducted molecular physiological analyses of the molecules involved in the sodium and calcium concentration control systems that are related to the generation of basic taste signals. The data suggested that Na, K-ATPase α1, β1, and FXYD6 formed a complex involved in sodium concentration control in type II taste cells, which respond to sweet, bitter, and umami tastes. In addition, we found that TRPM5 could bind to Jaw1 in heterologous expression systems. These results suggest that the complex of inositol triphosphate (IP3) receptor type III, TRPM5, and Jaw1 is involved in IP3-calcium signaling in type II taste cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (1 results)

All 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] FXYD6, a Na,K-ATPase Regulator, Is Expressed in Type II Taste Cells2011

    • Author(s)
      進藤洋一郎、森下加奈、小竹英一、三浦裕仁、カルニンチピエロ、河合純、林崎良英、日野明寛、神田智正、日下部裕子
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 6 Pages: 1061-1066

    • DOI

      10.1271/bbb.100718

    • NAID

      10029327838

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi