| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We conducted molecular physiological analyses of the molecules involved in the sodium and calcium concentration control systems that are related to the generation of basic taste signals. The data suggested that Na, K-ATPase α1, β1, and FXYD6 formed a complex involved in sodium concentration control in type II taste cells, which respond to sweet, bitter, and umami tastes. In addition, we found that TRPM5 could bind to Jaw1 in heterologous expression systems. These results suggest that the complex of inositol triphosphate (IP3) receptor type III, TRPM5, and Jaw1 is involved in IP3-calcium signaling in type II taste cells.
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