Mechanism of gene expression regulation of anti-oxidant enzymeswith oxidative stress in fishes - Molecular cell biological approach -
| Project/Area Number |
22580224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
OSATOMI Kiyoshi 長崎大学, 水産・環境科学総合研究科, 教授 (40253702)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Kenji 長崎大学, 水産・環境科学総合研究科, 教授 (10039737)
ODA Tatsuya 長崎大学, 水産・環境科学総合研究科, 教授 (60145307)
KANAI Kinya 長崎大学, 水産・環境科学総合研究科, 教授 (40145222)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗酸化酵素 / プロモーター / 酸化ストレス / 魚病細菌 / 細胞培養系 |
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| Research Abstract |
In this study, we examined the effects of extracellular products(ECP) from Edwardsiella tarda (E.tarda) strains on macrophages in terms of the induction of NO and TNF-α. ECP from virulent strain (NUF251) of E.tarda stimulated macrophages to induce NO and TNF-αproductions in a concentration-dependent manner. Proteomic analysis of ECP from E.tarda strains suggested that NUF251-specific protein, which has sequence homology with flagellin, is present in NUF251-ECP as a main component.
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Report
(4 results)
Research Products
(6 results)
