Studies on thick filament formation during myofibrillogenesis
Project/Area Number |
22580301
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Zootechnical science/Grassland science
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OJIMA Koichi 畜産草地研究所, 畜産物研究領域, 主任研究員 (60415544)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 骨格筋 / ミオシン / 太いフィラメント / 筋原線維 |
Research Abstract |
Thick filaments are composed of more than 300 myosin molecules in myofibrils. In this study, we found that the light meromyosin (LMM), which is one of myosin heavy chain (Myh) domains, was essential to form thick filaments in cultured skeletal muscle cells. Furthermore, to form thick filaments of LMM was facilitated by the presence of the subfragment-2 (S2), although solely expressed S2 did not form thick filaments, suggesting that the S2 may regulate thick filament formation.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] Myosin dynamicsin cultured skeletal muscle cells.2012
Author(s)
Yasukawa, Y., Ojima, K., Wakamatsu, J.-i.,Hattori, A., and Nishimura, T.
Organizer
2012 Annual Meeting of the American Society for Cell Biology
Place of Presentation
The Moscone Center, San Francisco, USA.
Year and Date
2012-12-17
Related Report
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[Presentation] The impact of each domain of myosin heavy chain molecule on forming thick filaments in muscle and non-muscle cells.2012
Author(s)
Ojima, K., Nakajima, I., Oe, M., Muroya, S.,Nishimura, T., and Hattori, A.
Organizer
2012 Annual Meeting of the American Society for Cell Biology
Place of Presentation
The Moscone Center, San Francisco, USA.
Year and Date
2012-12-17
Related Report
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