Mechanisms of the growth inhibition in social defeat model of rats
| Project/Area Number |
22580303
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Zootechnical science/Grassland science
|
|---|
| Research Institution | Ibaraki University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CHONAN Shigeru 茨城大学, 農学部, 准教授 (70312775)
KOHARI Daisuke 茨城大学, 農学部, 准教授 (50396595)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 畜産学 / ストレス / マロニル-CoA / うつ病 / 視床下部 / 成長 / 神経科学 / 栄養学 / マロニル－CoA |
|---|
| Research Abstract |
This research focused on the growth inhibition in social defeated model of rats using the resident-intruder paradigm. The defeated model of rats showed anorexia-like symptoms following growth inhibition. Possibly, this was based on the disruption of hypothalamic regulation for feeding behaviors including malonyl-CoA signal pathway, because malonyl-CoA level in the hypothalamus of defeated rats abnormally increased.
|
Report
(4 results)
Research Products
(32 results)
