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Mechanisms of the growth inhibition in social defeat model of rats

Research Project

Project/Area Number 22580303
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionIbaraki University

Principal Investigator

TOYODA Atsushi  茨城大学, 農学部, 准教授 (00292483)

Co-Investigator(Kenkyū-buntansha) CHONAN Shigeru  茨城大学, 農学部, 准教授 (70312775)
KOHARI Daisuke  茨城大学, 農学部, 准教授 (50396595)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords畜産学 / ストレス / マロニル-CoA / うつ病 / 視床下部 / 成長 / 神経科学 / 栄養学 / マロニル-CoA
Research Abstract

This research focused on the growth inhibition in social defeated model of rats using the resident-intruder paradigm. The defeated model of rats showed anorexia-like symptoms following growth inhibition. Possibly, this was based on the disruption of hypothalamic regulation for feeding behaviors including malonyl-CoA signal pathway, because malonyl-CoA level in the hypothalamus of defeated rats abnormally increased.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (24 results) Remarks (2 results)

  • [Journal Article] Effect of diet composition on coenzyme A and its thioester pools in various rat tissues2012

    • Author(s)
      徳竹由華、飯尾恒、鬼澤直樹、緒形雄太、小針大助、豊田淳、長南茂
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: VOL. 423 Issue: 4 Pages: 781-784

    • DOI

      10.1016/j.bbrc.2012.06.037

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats2012

    • Author(s)
      Iio W, Tokutake Y, Matsukawa N, Tsukahara T, Chohnan S, Toyoda A
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 421(2) Issue: 2 Pages: 301-304

    • DOI

      10.1016/j.bbrc.2012.04.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats2012

    • Author(s)
      Wataru Iio ; Yuka Tokutake ; Noriko Matsukawa.; Takamitsu Tsukahara ; Shigeru Chohnan, Atsushi Toyoda
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 421(2) Pages: 301-304

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic social defeat stress on MAP kinase cascade2011

    • Author(s)
      Iio W, Matsukawa N, Tsukahara T, Kohari D, Toyoda A
    • Journal Title

      Neuroscience letters

      Volume: 504(3) Issue: 3 Pages: 281-284

    • DOI

      10.1016/j.neulet.2011.09.047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme A and its thioester pools in fasted and fed rat tissues2010

    • Author(s)
      Tokutake Y, Onizawa N, Katoh H, Toyoda A, Chohnan S
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 402(1) Issue: 1 Pages: 158-162

    • DOI

      10.1016/j.bbrc.2010.10.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme A and its thioester pools in fasted and fed rat tissues2010

    • Author(s)
      Yuka Tokutake, ら
    • Journal Title

      Biochemical, Biophysical Research Communications

      Volume: 402 Pages: 158-162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 慢性的社会性ストレスによる摂食不振は視床下部マロニル-CoA濃度の 上昇によっておこる2012

    • Author(s)
      飯尾 恒、小池広明、徳竹由華、松川典子、塚原隆充、長南 茂、豊田 淳
    • Organizer
      関東畜産学会
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性的社会性ストレスモデル動物における摂食量および体重の変化2012

    • Author(s)
      田中勇気、飯尾 恒、豊田 淳
    • Organizer
      関東畜産学会
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Anorexia and hypothalamic malonyl- CoA signaling pathway in chronic social defeated rats2012

    • Author(s)
      飯尾 恒、徳竹由華、松川典子、塚原隆充、長南 茂、豊田 淳
    • Organizer
      北米神経科学会
    • Place of Presentation
      アメリカ
    • Year and Date
      2012-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 高脂肪食がラット組織内CoAプー ルに及ぼす影響2012

    • Author(s)
      徳竹 由華, 飯尾 恒, 豊田 淳, 長南 茂
    • Organizer
      第33回肥満学会
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的慢性ストレスを曝露されたラットは視床下部マロニル-CoA濃度が増加し、摂食行動が抑 制される2012

    • Author(s)
      飯尾 恒,徳竹 由華,松川 典子,塚原 隆充, 長南 茂,豊田 淳
    • Organizer
      第35回日本神経科学大会
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Modification of the Acyl-CoA Cycling Method for Analysis of CoA Pools2012

    • Author(s)
      Y. TOKUTAKE, A. SAIJO, W. IIO, Y. OGATA, A. TOYODA, S. CHOHNAN
    • Organizer
      米国微生物学会
    • Place of Presentation
      アメリカ
    • Year and Date
      2012-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的慢性ストレスモデルにおける増体抑制メカニズムの解明2012

    • Author(s)
      飯尾恒、徳竹、由華、松川典子、塚原隆充、長南茂、豊田淳
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 社会的慢性ストレスモデルにおける増体抑制メカニズムの解明2012

    • Author(s)
      飯尾 恒、徳竹、由華、松川 典子、塚原 隆充、長南 茂、豊田 淳
    • Organizer
      日本畜産学会第115回大会
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的慢性ストレスがラット白色脂肪および脾臓の TNF-α、IL-6、レプチンの遺伝子発現に及ぼす影響2012

    • Author(s)
      高木 良治、飯尾 恒、瀬尾 優太、松川 典子、塚原 隆充、豊田 淳、宮口 右二、小川 恭喜
    • Organizer
      日本畜産学会第115回大会
    • Related Report
      2012 Final Research Report
  • [Presentation] 高脂肪食がラット組織内CoAプー ルに及ぼす影響2012

    • Author(s)
      徳竹由華
    • Organizer
      日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 社会的慢性ストレスを曝露されたラットは視床下部マロニル-CoA濃度が増加し、摂食行動が抑 制される2012

    • Author(s)
      飯尾恒
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 絶食および飽食ラットにおける組織内CoAプールの動態解析2011

    • Author(s)
      徳竹由華, ら
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 社会的ストレス誘導型うつ病モデルラットにおける増体抑制機序の解明2011

    • Author(s)
      松川典子, ら
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 4週間のタウリン給与における抗うつ効果の行動学的評価2011

    • Author(s)
      飯尾恒, ら
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食餌の質がラット組織内CoAプールに及ぼす影響2011

    • Author(s)
      徳竹 由華、鬼澤 直樹、飯尾 恒、豊田 淳、長南 茂
    • Organizer
      第32回日本肥満学会
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性的社会性ストレスと急性ストレスラットでの小腸消化吸収能の違い2011

    • Author(s)
      松川 典子、飯尾 恒、豊田 淳、中山 啓三、原 博、塚原 隆充
    • Organizer
      日本栄養食糧学会
    • Related Report
      2012 Final Research Report
  • [Presentation] 絶食および飽食ラットにおける組織内CoAプールの動態解析2011

    • Author(s)
      徳竹 由華、鬼澤 直樹、村田 恵、渡辺 央好、角田 梨奈、豊田 淳、長南 茂
    • Organizer
      日本農芸化学会
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的ストレス誘導型うつ病モデルラットにおける増体抑制機序の解明2011

    • Author(s)
      松川 典子、飯尾 恒、豊田 淳、中山 啓三、原 博、塚原 隆充
    • Organizer
      日本農芸化学会
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会的ストレスによるうつ病モデルラットの増体抑制はなぜ起こるのか2010

    • Author(s)
      松川典子, ら
    • Organizer
      Hindgut Club Japan シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 社会的ストレスによるうつ病モデルラットの増体抑制はなぜ起こるのか?2010

    • Author(s)
      松川典子、飯尾恒、豊田淳、原博、塚原隆充
    • Organizer
      第16回Hindgut Club Japanシンポジウム
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性的社会性ストレスによる摂食不振は視床下部マロニル-CoA濃度の 上昇によっておこる

    • Author(s)
      飯尾恒
    • Organizer
      関東畜産学会
    • Place of Presentation
      茨城大学農学部
    • Related Report
      2012 Annual Research Report
  • [Presentation] 慢性的社会性ストレスモデル動物における摂食量および体重の変化

    • Author(s)
      田中勇気
    • Organizer
      関東畜産学会
    • Place of Presentation
      茨城大学農学部
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anorexia and hypothalamic malonyl- CoA signaling pathway in chronic social defeated rats

    • Author(s)
      飯尾恒
    • Organizer
      北米神経科学会
    • Place of Presentation
      ニューオリンズ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modification of the Acyl-CoA Cycling Method for Analysis of CoA Pools

    • Author(s)
      徳竹由華
    • Organizer
      米国微生物学会
    • Place of Presentation
      ニューオリンズ
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://doubutu.agr.ibaraki.ac.jp/siryou/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      https://www.facebook.com/pages/%E8%8C%A8%E5%9F%8E%E5%A4%A7%E5%AD%A6%E8%BE%B2%E5%AD%A6%E9%83%A8%E9%A3%BC%E6%96%99%E8%B3%87%E6%BA%90%E7%A7%91%E5%AD%A6%E7%A0%94%E7%A9%B6%E5%AE%A4/183029258445748

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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