Critical role of hypothalamic dopamine in regulation of food intake by growing chickens on lysine-free diet

• Project/Area Number: 22580304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Utsunomiya University
• Principal Investigator: SUGAHARA Kunio 宇都宮大学, 農学部, 教授 (50091947)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 栄養・飼養 / 摂食量 / 視床下部 / モノアミン / 脳微小透析法 / リジン欠乏 / ドーパミン / 鶏ヒナ / 血漿アミノ酸濃度 / food intake / hypothalamus / monoamines / brain microdyalysis / chicken / brain microdialysis

Research Abstract

1.Central perfusion of L-DOPA as well as peripheral administration of lysine kept the extracellularDA level in the VMH at baseline of chickens fed on a lysine-free diet.
2. Keeping the extracellular DA level in the VMH prevents chickens on the lysine-free diet prevented from decreasing their voluntary food intake.
3. DA in the VMH plays a critical role in food intake regulation in chickens fed on a lysine-free diet.

Research Products

• [Journal Article] Oral administration of lysine restores food intake and ventromedial hypothalamic (2012)
  • Author(s): M.R. Alam , F. Yoshizawa and K. Sugahara
  • Journal Title: dopamine in chicken on a lysine-free diet British Poultry Science Volume: 53 Pages: 651-657
  • URL: http://dx.doi.org/10.1080/00071668.2012.726349
  • Peer Reviewed
• [Journal Article] Local administration of L-DOPA in the chicken ventromedial hypothalamus increases (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa, Kunio Sugahara
  • Journal Title: dopamine release in a dose-dependent manner Neuroscience Letters Volume: 529 Pages: 150-154
  • URL: http://dx.doi.org/10.1016/j.neulet.2012.08.054
  • Peer Reviewed
• [Journal Article] Local administration of L-DOPA in the chicken ventromedial hypothalamus increases dopamine release in adose-dependent manner (2012)
  • Author(s): Mohammad Rashedul Alam
  • Journal Title: Neuroscience Letters Volume: 529 Pages: 150-154
  • Peer Reviewed
• [Journal Article] Oral administration of lysine restores food intake and ventromedial hypothalamic dopamine in chicken on a lysine-free diet (2012)
  • Author(s): Mohammad Rashedul Alam
  • Journal Title: British Poultry Science Volume: 53 Issue: 5 Pages: 651-657
  • DOI: 10.1080/00071668.2012.726349
  • Peer Reviewed
• [Journal Article] L-DOPA induced extracellular dopamine increases in the ventromedial hypothalamus affects food intake by chickens on a lysine-free diet (2011)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa, Kunio Sugahara
  • Journal Title: Neuroscience Letters Volume: 495 Pages: 126-129
  • URL: http://dx.doi.org/10.1016/j.neulet.2011.03.053
  • Peer Reviewed
• [Journal Article] L-DOPA induced extracellular dopamine increases in the ventromedial hypothalamus affects food intake by chickens on a lysine-free diet (2011)
  • Author(s): Mohammad Rashedul Alam, 他
  • Journal Title: Neuroscience Letters Volume: Doi:10.1016/j.neulet2011.03.053 Pages: 126-129
  • Peer Reviewed
• [Journal Article] 採卵鶏栄養における最新情報について (2010)
  • Author(s): 菅原邦生
  • Journal Title: 関東畜産学会報 Volume: 61 Pages: 9-18
  • Peer Reviewed
• [Journal Article] Oral administration of lysine restores food intake and ventromedial hypothalamic dopamine in chicken on a lysine-free diet
  • Author(s): Mohammad Rashedul Alam, ら
  • Journal Title: British Poultry Science Volume: (受理)
  • Peer Reviewed
• [Presentation] 第15回Asian-Australasian AnimalProduction Conference (タイ、バンコク) (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa and Kunio Sugahara
  • Organizer: Voluntary food intake variation in growingchickens on lysine-free diet is attributed to the plasma lysine level
• [Presentation] 日本家禽学会2012年春季大会(名古屋) (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa and Kunio Sugahara
  • Organizer: Oral administration of lysine resotres food intake and ventromedial hypothalamic dopamine in chickens on a lysine-free diet
• [Presentation] Voluntary food intake variation in growing chickens on lysine-free diet is attributed to the plasma lysine level (2012)
  • Author(s): Mohammad Rashedul Alam
  • Organizer: 第15回Asian-Australasian Animal Production Conference
  • Place of Presentation: バンコック、タイ
• [Presentation] Feeding lysine-free diet increases plasma corticosterone level in growing chickens (2012)
  • Author(s): Kunio Sugahara
  • Organizer: 第10回鳥類内分泌国際シンポジウム
  • Place of Presentation: 岐阜
• [Presentation] ヒナの血漿コルチコステロン濃度はリジン欠乏飼料摂取により増加する (2011)
  • Author(s): 菅原邦生, ら
  • Organizer: 日本家禽学会2011年度秋季大会
  • Place of Presentation: 十和田市北里大学獣医学部
  • Year and Date: 2011-08-25
• [Presentation] Regulation of voluntary food intake in chickens (2011)
  • Author(s): Kunio Sugahara
  • Organizer: 9^<th> Asia Pacific Poultry Conference
  • Place of Presentation: 台北
  • Year and Date: 2011-03-22
• [Presentation] Regulation of voluntary food intake in chickens (2011)
  • Author(s): Kunio Sugahara
  • Organizer: 第9回Asian Pacific Poultry Conference(台北、台湾)招待講演
• [Presentation] Extracellular dopamine in the ventromedial hypothlamus increases after administration of nomifensine and L-dopa in freely moving chicks as measured by brain microdialysis (2010)
  • Author(s): Mohammad Raehedul Alam, Fumiaki Yoshizawa, Kunio Sugahara
  • Organizer: 第21回マイクロダイアリシス研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-11
• [Presentation] Manipulation of extracellular dopamine level in the ventromedial hypothlamus affects food intake by chickens on lysine-free diet (2010)
  • Author(s): Mohammad Rashedul Alam, Fumiaki Yoshizawa, Kunio Sugahara
  • Organizer: 第35回鳥類内分泌研究会
  • Place of Presentation: 岡山
  • Year and Date: 2010-11-25
• [Presentation] Extracellular dopamine in the ventromedial hypothalamus increases after administration of Nomifensine and L-DOPA in freely moving chicks as measured by brain microdialysis (2010)
  • Author(s): Alam M. Rashedul, Fumiaki Yoshizawa andKunio Sugahara
  • Organizer: 第21回マイクロダイアリシス研究会(東京)
• [Presentation] Manipulation of extracellular dopamine level in the ventromedial hypothalamus affects (2010)
  • Author(s): Alam M. Rashedul, Fumiaki Yoshizawa andKunio Sugahara
  • Organizer: 第35回鳥類内分泌研究会(岡山)
• [Book] Chapter I Neuroendocrine regulation of sedation and excitation in neonatal chicks (2013)
  • Author(s): Takashi Bungo and Kunio Sugahara
  • Publisher: In Hormones and Behavior Ed. Davis Simonsen, Nova science publ.Inc.
• [Book] Neuroendocrine regulation of sedation and excitation in neonatal chicks (2012)
  • Author(s): Mitsuhiro Furuse
  • Total Pages: 170
  • Publisher: Nova Science Publisher Inc.
• [Book] 畜産学入門 (2012)
  • Author(s): 唐沢豊
  • Total Pages: 306
  • Publisher: 文永堂出版株式会社
• [Remarks]
  • URL: http://agri.mine.utsunomiya-u.ac.jp/hpj-deptj/anij/nutri/images/sugahara.pdf
• [Remarks]
  • URL: http://agri.mine.utsunomiya-u.ac.jp/hpj/deptj/anij/item/sugahara.html