| Project/Area Number |
22580305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
ARAI Katsuhiko 東京農工大学, 農学部附属硬蛋白質利用研究施設, 教授 (60175940)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | コラーゲン / 筋 / p53 / ΔNp73 / 筋分化 / XII型コラーゲン / p53ファミリー / 細網線維 / XIV型コラーゲン / 筋肉 / C2C12 / 線維芽細胞 |
|---|
| Research Abstract |
The type XII collagen, which was thought to accelerate fibrogensis, was upregulated during myoblast differentiation. To identify the transcription factor that regulate expression of type XII collage gene, it was found that tumor suppressor protein, p53 bind the regulatory region of the gene and p53-inhibitor, DNp73 stimulated expression of the gene. Thus, p53 family regulated extracellular matrix during myogenesis.
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