| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The regulatory mechanism of bird PRL in the anterior pituitary gland is unique and completely different to that of mammalian PRL. The aims of this study were cloning of chicken PREB and comparison of levels of mRNA expression in the various tissues during embryogenesis. Chicken PREB cDNA shows 70% similarity to human and rat PREB cDNAs. The levels of PREB mRNA showed tissue dependent manner. Interestingly, the changes of levels of PREB mRNA had not been observed in the anterior pituitary gland during embryogenesis. These results suggest that PREB protein participate regulation of various gene. Furthermore, PREB involves activation of PRL gene rather than increase of mRNA levels during late stage of embryogenesis.
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