| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The roles of PAR (protease activated receptor） in the intestinal myofibroblast do not fully understand. So, we designed this project to clarify the role of PAR and the control mechanisms of the expression of PAR in intestinal myofibroblasts. We found that the expression level of PAR in the whole cell by the stimulation with cytokines was not changed, but PAR was moved from membrane to cytosolic area. We also found that prostaglandin E2-induced cAMP is contributed in this mechanism.
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