Induction of alternative activation of macrophages and alterationsin intestinal epithelial cell function by Th2 cytokines for type 2 diabetes therapy
| Project/Area Number |
22580337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / マクロファージ / 寄生虫 / GLUT / 2型糖尿病 / 線虫 / 2型免疫応答 / インスリン抵抗性 / 糖輸送担体 / 非炎症性マクロファージ / サイトカイン / 肝臓 / 脂肪組織 / 小腸 / マウス |
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| Research Abstract |
KK-Ay/TaJｃl mice, an animal models of type 2 diabetes were inoculated with infective third-stage Heligmosomoides polygyrus (Hp) larvae and studied at day8 after infection. Th2 cytokine gene expression was elevated, and AAMacs were accumulated in the small intestine. The gene expression of GLUT-2 and SGLT-1 was down regulated. Helminth infection could reduce blood glucose level and the liver enzyme levels and improve a fatty liver. Inducing intestinal AAMacs by Hp infection could have therapeutic importance for T2D.
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Report
(4 results)
Research Products
(4 results)
