| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
KK-Ay/TaJｃl mice, an animal models of type 2 diabetes were inoculated with infective third-stage Heligmosomoides polygyrus (Hp) larvae and studied at day8 after infection. Th2 cytokine gene expression was elevated, and AAMacs were accumulated in the small intestine. The gene expression of GLUT-2 and SGLT-1 was down regulated. Helminth infection could reduce blood glucose level and the liver enzyme levels and improve a fatty liver. Inducing intestinal AAMacs by Hp infection could have therapeutic importance for T2D.
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