| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
α2,3-sialyltransferase (ST3Gal IV) is involved in developments of epilepsy, anxiety, depression, and sleep disorder. In this study, I aimed at the elucidation of the molecular mechanisms of these neuropsychiatric symptoms by using mice deficient for ST3Gal IV gene. Finally, we found that ST3Gal IV controlled the expression level of brain growth hormone that enhances progression of epileptic seizures and was associated with brain lipid metabolism system and production of steroid hormone.
|
