| Project/Area Number |
22580347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
WATANABE Atsushi 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 主任研究員 (60442810)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Eiji 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 主任研究員 (50355153)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Kazuhiro 北海道大学, 大学院・獣医学研究科, 教授 (30192561)
HIRAI Tsunao 地方独立行政法人北海道立総合研究機構, 畜産試験場, 研究主幹 (80390855)
KIMURA Takashi 北海道大学, 人獣共通感染症リサーチセン ター, 准教授 (90261338)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 乳牛 / 乳房炎 / 黄色ブドウ球菌 / 好中球 / インターロイキン-8 / エラスターゼ / ラクトフェリン由来ペプチド / 乾乳期乳房炎 / 細胞外トラップ / ロイコシジン / 獣医学 / 感染症 / 免疫学 / 生体分子 / 動物 |
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| Research Abstract |
The dry period bovine mastitis caused by Staphylococcus aureus infection shows characteristic pathogenesis that is lastingly developed. We showed that interleukin-8 (IL-8), leukocyte elastase, and inflammatory lactoferrin-derived peptides were released, in relation with the pathogenesis of S. aureus dry period mastitis, in mastitic mammary secretions. In the chronic stage of the mastitis, transforming growth factor-β2 that suppresses IL-8 secretion was suggested to be involved in subsiding of the inflammation.
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