Study on bovine leukemia virus integration site and genomic mutationsin cattle that develop leukemia.
| Project/Area Number |
22580357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Kenji 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 上席研究員 (10355141)
SUZUKI Kazuhiko 東京農工大学, 農学部, 講師 (00366626)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 家畜衛生 / 遺伝子 / ウイルス / 癌 / 細胞 / 組織 / 獣医学 / 牛白血病 / 細胞・組織 / 伝染病 |
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| Research Abstract |
The integration sites of bovine leukemia virus(BLV)in leukemiccells were analyzed using 90 tumor tissues from 48 0f leukemic cattle. Although the integration sites were not located in a particular chromosome, the BLV provirus wasintegrated into transcription units at a frequency of 43.6% and the transcriptional direction of the proviruswas in accordance with that of the integrated host genes in 62.5%.The integration sites were located in introns of the host gene, excluding only one site.BLV provir1.ts did not favor integration near transcription start sites and CpG islands.It is suggested that the integration site of the BLV provirus in leukemi ceells is relatedto the suppression of viral gene expression.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] 牛白血病ウ2013
Author(s)
宮坂卓、小熊圭祐、泉封博.
Organizer
第155回日本獣医学会学術集会
Place of Presentation
東京大学教養学部
Year and Date
2013-03-29
Related Report
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