Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect.
| Project/Area Number |
22580360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
SASAKI Naoki 帯広畜産大学, 畜産学部, 准教授 (00360975)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 再生医療 / 骨 / 関節軟骨 / ゼラチンハイドロゲル / 骨形成蛋白 / 多血小板血漿 / 生体組織工学 / 足場 / ドラックデリバリーシステム / 幹細胞 / ウマ / 骨折 / 軟骨 / 骨スクリュー / スキヤフォールド |
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| Research Abstract |
β-TCP sponge was an excellent scaffold material, which builds a DDS for BMP-2. Based on these results, it was shown that the combined use of growth factors and scaffolds is effective in bone regeneration. it was suggested that the combined use of MSC, BMP-2 and □-TCP sponge efficiently promoted bone regeneration. Based on the results of the five studies, it was demonstrated that the application of tissue engineering combining growth factors, cells, and scaffolds promoted bone and articular cartilage regeneration. Therefore, future clinical applications to bone and articular cartilage diseases of horses are expected.
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Report
(4 results)
Research Products
(26 results)
