| Project/Area Number |
22580361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TANI Kenji 山口大学, 共同獣医学部, 准教授 (00365420)
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| Co-Investigator(Kenkyū-buntansha) |
TAURA Yasuho 山口大学, 共同獣医学部, 教授 (80163153)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 犬 / 骨髄間質細胞 / 肝障害 / 再生医療 / 慢性肝炎 / 骨髄細胞 / 肝線維症 / マトリックスメタロプロテアーゼ / 肝不全 |
|---|
| Research Abstract |
To evaluate canine BMSCs transplantation for regenerative liver therapy, we used two different models; nude mice and cyclospoline A (CSA) immunosuppressive mice for xenotransplantation. Transplanted canine BMSCs migrate effectively only into a persistently injured liver of CCl4/CSA mice, which in turn canine BMSCs may be effective to resolve inflammatory fibrosis lesions. Since cultured canine BMSCs produce matrix metalloproteinases (MMPs), therapeutic potential of canine BMSCs therapy may be associated with MMPs expression.
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