| Project/Area Number |
22580365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KAWATE Noritoshi 大阪府立大学, 大学院・生命環境科学研究科, 准教授 (80221901)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masahiro 大阪府立大学, 大学院・生命環境科学研究科, 助教 (50582334)
TAMADA Hiromichi 大阪府立大学, 大学院・生命環境科学研究科, 教授 (10155252)
INABA Toshio 大阪府立大学, 大学院・生命環境科学研究科, 教授 (00137241)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 臨床繁殖 / 産科 / INSL3 / イヌ / ウシ / 潜在精巣 / テストステロン / ライディッヒ細胞 / EIA法 / TR-FIA法 / 雄イヌ / 雄ウシ / 性成熟過程 / 精巣 / 精巣間質細胞(ライディッヒ細胞) / 酵素免疫測定法(EIA法) |
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| Research Abstract |
We established immunoassays for canine and bovine insulin-peptide 3 (INSL3) and examined changes of the hormone secretion during sexual maturation and aging in male animals. We also analyzed the INSL3 secretion in cryptorchid cases to examine pathological condition and application to its diagnosis. As the results, the change of INSL3 concentration differed from those of testosterone during puberty. It is elucidated that endocrine function of testicular Leydig cells is reduced in cryptorchid cases. Also, it is suggested that retained testis can be predicted by measuring INSL3 in dogs without testis in scrotum.
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