| Project/Area Number |
22580367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
UENO Hiroshi 酪農学園大学, 獣医学群, 教授 (70322881)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 犬 / 椎間板疾患 / 予後判定因子 / マトリックスメタロプロテイナーゼ / 軟骨異栄養犬種 / 血清 / ゼラチンザイモグラフィー / マトリクスメタロプロテイナーゼ / MMP活性値 / 歯周病 / 歯肉 / 軟骨異栄養種犬 / 予後因子 / 椎間板髄核 |
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| Research Abstract |
Canine progressive myelomalacia (PM) is a death-dealing disease which happen in succession to acute thoracolumbar intervertebral disc hernia (IVDH). Therefore, in order to determine a treatment policy, it is important to evaluate a possibility that in early stages of IVDH comes worse at PM. However, the sure factor for evaluating the possibility of PM generating does not exist. In this study, the matrix metalloproteinase (MMP) activity in serum of acute thoracolumbar IVDH dogs was evaluated. As a result, the serum MMP activity of PM case was increased than that of the healthy dog significantly. The MMP activity in serum of PM case was also increased than that of IVDH cases without deep pain (Grade V; GV) significantly. From these results, a possibility that the MMP activity value in serum would be applicable as an evaluation factor of PM generating was suggested.
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