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Evaluation of the biomarker of the prognosis in dogs with thoracolumbar intervertebral disc disease

Research Project

Project/Area Number 22580367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionRakuno Gakuen University

Principal Investigator

UENO Hiroshi  酪農学園大学, 獣医学群, 教授 (70322881)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords犬 / 椎間板疾患 / 予後判定因子 / マトリックスメタロプロテイナーゼ / 軟骨異栄養犬種 / 血清 / ゼラチンザイモグラフィー / マトリクスメタロプロテイナーゼ / MMP活性値 / 歯周病 / 歯肉 / 軟骨異栄養種犬 / 予後因子 / 椎間板髄核
Research Abstract

Canine progressive myelomalacia (PM) is a death-dealing disease which happen in succession to acute thoracolumbar intervertebral disc hernia (IVDH). Therefore, in order to determine a treatment policy, it is important to evaluate a possibility that in early stages of IVDH comes worse at PM. However, the sure factor for evaluating the possibility of PM generating does not exist. In this study, the matrix metalloproteinase (MMP) activity in serum of acute thoracolumbar IVDH dogs was evaluated. As a result, the serum MMP activity of PM case was increased than that of the healthy dog significantly. The MMP activity in serum of PM case was also increased than that of IVDH cases without deep pain (Grade V; GV) significantly. From these results, a possibility that the MMP activity value in serum would be applicable as an evaluation factor of PM generating was suggested.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2013

All Presentation (3 results)

  • [Presentation] Evaluation of matrix metalloproteinase (MMP)-9 as a biomarker of the prognosis in dogs with thoracolumbar intervertebral disc hernia (IVDH)2013

    • Author(s)
      H. Ueno, Y. Fujisaki, T. Matsunagi, S. Isoda, H. Soma, K. Fujita
    • Organizer
      26th Annual Symposium of ESVN and ECVN
    • Place of Presentation
      Paris
    • Year and Date
      2013-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常犬における血清中マトリックスメタロプロテイナーゼ-9活性の評価2013

    • Author(s)
      磯田成志、藤崎雄介、馬緤智之、相馬浩晶、藤田和繁、上野博史
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2013-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 犬の胸腰部椎間板ヘルニアの予後判定因子としての血清中Matrix Metalloproteinase-9 (MMP- 9)の有用性2013

    • Author(s)
      上野博史、藤崎雄介、馬緤智之、磯田成志、相馬浩晶、藤田和繁
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2013-09-22
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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