Evaluation of effect for insulin signaling and insulin resistance in feline obesity.

• Project/Area Number: 22580370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: SAKO Toshinori 日本獣医生命科学大学, 獣医学部, 教授 (70153971)
• Co-Investigator(Kenkyū-buntansha): MORI Akihiro 日本獣医生命科学大学, 獣医学部, 助教 (60549559)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 糖尿病 / 猫 / インスリン / 人工膵臓 / インスリン抵抗性 / 肥満

Research Abstract

This study suggested feline obesity induce decreased expression of insulin signaling and it leads insulin resistance. Also, high carbohydrate diet induces high insulin response in obese cats.

Research Products

• [Journal Article] Impact of Commercially Available Diabetic Prescription Diets on Short-Term Postprandial Serum Glucose, Insulin, Triglyceride and Free Fatty Acid Concentrations of Obese Cats (2013)
  • Author(s): Mimura K, Mori A, Lee P, Ueda K, Oda H, Saeki K, Arai T, Sako T.
  • Journal Title: Journal of Veterinary Medical Science Volume: 75 Issue: 7 Pages: 929-937
  • DOI: 10.1292/jvms.12-0310
  • NAID: 130003362136
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Journal Article] Comparison of Glucose Fluctuations between Day- and Night-Time Measured Using a Continuous Glucose Monitoring System in Diabetic Dogs (2013)
  • Author(s): Mori A, Kurishima M, Oda H, Saeki K, Arai T, Sako T.
  • Journal Title: Journal of Veterinary Medical Science Volume: 75 Issue: 1 Pages: 113-117
  • DOI: 10.1292/jvms.12-0123
  • NAID: 130002090088
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Journal Article] Characterization and Comparison of Insulin Resistance Induced by Cushing Syndrome or Diestrus against Healthy Control Dogs as Determined by Euglycemic- Hyperinsulinemic Glucose Clamp Profile Glucose Infusion Rate Using an Artificial Pancreas Apparatus (2012)
  • Author(s): Fukuta H, Mori A, Urumuhan N, Lee P, Oda H, Saeki K, Kurishima M, Nozawa S,Mizutani H, Mishina S, Arai T, Sako T.
  • Journal Title: Journal of Veterinary Medical Science Volume: 74 Issue: 11 Pages: 1527-1530
  • DOI: 10.1292/jvms.12-0041
  • NAID: 130001879712
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Journal Article] Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats (2011)
  • Author(s): Lee P, Mori A, Takemitsu H, Yamamoto I, Arai T
  • Journal Title: The Veterinary Journal Volume: 190 Issue: 2 Pages: 150-153
  • DOI: 10.1016/j.tvjl.2011.04.003
  • Peer Reviewed
• [Journal Article] Evaluation of artificial pancreas technology for continuous blood glucose monitoring in dogs (2011)
  • Author(s): Mori A, Lee P, Yokoyama T, Oda H, Saeki K, Miki Y, Nozawa S, Azakami D, MomotaY, Makino Y, Matsubara T, Osaka M, Ishioka K, Arai T, Sako T
  • Journal Title: Journal of Artificial Organs Volume: 14 Issue: 2 Pages: 133-139
  • DOI: 10.1007/s10047-011-0560-1
  • NAID: 10029565927
  • Peer Reviewed
• [Journal Article] Age-specific plasma biochemistry reference ranges in<1 year old dogs in Japan (2011)
  • Author(s): Sako T, Mori A, Lee P, et al
  • Journal Title: Vet Res Commun Volume: 35 Issue: 4 Pages: 201-209
  • DOI: 10.1007/s11259-011-9463-0
  • Peer Reviewed
• [Journal Article] Time-action profiles of insulin detemir in normal and diabetic dogs (2011)
  • Author(s): Sako T, Mori A, Lee P, Oda H, Saeki K, Miki Y, Kurishima M, Miura K, Nozawa S, Mizutani H, Makino Y, Ishioka K, Arai T
  • Journal Title: Research in Veterinary Science Volume: 90 Issue: 3 Pages: 396-403
  • DOI: 10.1016/j.rvsc.2010.07.001
  • Peer Reviewed
• [Journal Article] Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan. (2011)
  • Author(s): Sako T, Mori A, Lee P, (他11,2番目)
  • Journal Title: Veterinary Research Communications Volume: 35 Pages: 201-209
  • Peer Reviewed
• [Journal Article] Time-action profiles of insulin detemir in normal and diabetic dogs. doi:10.1016/j.rvsc.2010.07.001 (2011)
  • Author(s): Sako T, Mori A, Lee P, (他10,2番目)
  • Journal Title: Research in Veterinary Science Volume: 90 Pages: 396-403
  • Peer Reviewed
• [Journal Article] Hypertriglyceridemia with increased plasma insulin concentrations in cats. (2010)
  • Author(s): Hatano Y, Mori N, Asada M, Mori A, Yamamoto I, Muranaka S, Kojima M, Kigure M, Yagishita M, Sako T, Arai T.
  • Journal Title: Res Vet Sci. Volume: Vol 88 Issue: 3 Pages: 458-460
  • DOI: 10.1016/j.rvsc.2009.12.012
  • Peer Reviewed
• [Journal Article] Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs. (2010)
  • Author(s): Sako T, Mori A, Lee P, (他11,2番目)
  • Journal Title: Veterinary Research Communications Volume: 34 Pages: 161-172
  • Peer Reviewed
• [Journal Article] Impact ofCommercially Available Diabetic Prescription Diets on Short-Term Post-PrandialSerum Glucose, Insulin, Triglyceride and Free Fatty Acid Concentrations of Obese Cats.
  • Author(s): Mimura K, Mori A, Lee P, Ueda K, Oda H, Saeki K, Arai T, Sako T.
  • Journal Title: J Vet Med Sci
  • URL: http://dx.doi.org/10.1292/jvms.12-0310
  • Peer Reviewed
• [Presentation] 肥満猫に対する糖尿病療法食が血清グルコースおよびインスリン濃度に与える影響について
  • Author(s): 上田香織、出雲梨花子、三村可菜、岡本理沙、木村友子、佐伯香織、小田民美、森昭博、左向敏紀
  • Organizer: 第14回日本ペット栄養学会