Establishment of assay system for vaccination adverse reaction and its clinical application.
Project/Area Number |
22580372
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Clinical veterinary science
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
MASUDA Kenichi 独立行政法人理化学研究所, ワクチンデザイン研究チーム, 客員研究員 (40313077)
|
Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Masahiro 麻布大学, 獣医学部, 教授 (20170590)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | マウス / イヌ / ウシ血清アルブミン / IgE / IgG / ワクチン / 犬 / 牛血清アルブミン / アレルギー / アナフィラキシー |
Research Abstract |
Recognition site of mouse IgG monoclonal antibody to bovine serum albumin was sequenced for development of recombinant canine IgE against bovine serum albumin. A thresfold of serum IgE concentration to induce in vivo allergic reaction was examined with PK test; however, ideal results were not obtained. It is necessary to select allergens used for this study.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan2012
Author(s)
Miyaji, K., Suzuki, A., Shimakura, H., Takase, Y., Kiuchi, A., Fujimura, M., Kurita, G., Tsujimoto, H. and Sakaguchi, M.
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Journal Title
Veterinary Immunology and Immunopathology
Volume: 145
Pages: 447-452
Related Report
Peer Reviewed
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