| Project/Area Number |
22580386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
WADA Ikuo 福島県立医科大学, 医学部, 教授 (40182969)
HATSUZAWA Kiyotaka 鳥取大学, 医学部, 教授 (20256655)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | オルガネラ工学 / ゴルジ体 / 小胞体 / Rabタンパク質 / 逆行輸送 / 小胞輸送 / RabGAP / 品質管理 |
|---|
| Research Abstract |
Secretory proteins are synthesized on the endoplasmic reticulum membranes. Only properly folded proteins can be packed into transport vesicles and transported to the Golgi apparatus. When the proteins are recognized as mal-folded proteins, they are captured and brought back to the ER via so-called retrograde pathways. In this study, we developed a new system by which you can observe and record the movement on this retrograde pathways in real time. And by using this system, we identified a series of proteins that control the retrograde pathways and revealed one aspect of this very complexed transport mechanism.
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