Development of Catalytic Synthetic Reactions with High Clark Number Elements (Without A small Amounts of Rare Metals)
Project/Area Number |
22590008
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Nagoya City University |
Principal Investigator |
KONDO Kazuhiro 名古屋市立大学, 大学院・薬学研究科, 准教授 (90277343)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 触媒的合成反応 / 有機化学 / クラーク数 / アリール化 / シアノシリル化 / ヒドロシリル化 / N-複素環カルベン / Duphos / 触媒 / 合成化学 / N-複素環型カルベン / 遷移金属 / 1,2-付加 / 触媒的不斉反応 / アルデヒド / ニッケル / ホウ素 |
Research Abstract |
1) The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives bearing an ortho-Me2PhSi group, and (ii) the use of potassium arylborates as aryl sources. 2) A method for cyanation reaction of carbonyl and imino compounds with trimethylsilyl cyanide in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6,-trimethylphenyl)imidazolium chloride and potassium tert-butoxide. has been developed.
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Report
(4 results)
Research Products
(4 results)