Development of novel synthetic method and its use for synthesis of natural products
| Project/Area Number |
22590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Koji 北海道医療大学, 薬学部, 講師 (80272962)
ABE Takumi 北海道医療大学, 薬学部, 助教 (80453273)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | インドールアルカロイド / 有機金属試薬 / クロスカップリング / インドリルボレート / ホウ素 / 抗腫瘍活性 / カロトリキシン / エリプチシン / パラジウム触媒 / 銅錯体 / 金属触媒 / ビシクロラクタム / アリール化反応 / セロトニン / 生理活性物質 / クロスカップリング反応 |
|---|
| Research Abstract |
Cross-coupling reaction of indolylborate was used for concise total synththesis of calothrixins A and B. Unprecedented use of CuOTf for 6π-electrocyclization was also found, which was successfully applied for the improved synthesis of ellipticine. Introduction of aryl substituents to bicyclic lactam ABH was performed by metal-catalyzed coupling process.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] Hibino, Enantioselective total synthesis of 1,3-disubstituted ・-carboline alkaloids, (-)-dichotomine A and (+)-dichotomide II2013
Author(s)
S. Tagawa, T. Choshi, A. Okamoto, T. Nishiyama, S. Watanabe, N. Hatae, M. Ishikura, S
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Journal Title
Eur. J. Org. Chem
Volume: 00
Issue: 9
Pages: 1805-1810
DOI
Related Report
Peer Reviewed
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[Journal Article] Hibino2012
Author(s)
K. Matsumoto, T. Choshi, M. Horai, Y. Zamami, K. Sasaki, T. Abe, M. Ishikura, N. Hatae, T. Iwamura, S. Tohyama, J. Nobuhiro, S
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 22
Pages: 4762-4762
Related Report
Peer Reviewed
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