| Project/Area Number |
22590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Koji 北海道医療大学, 薬学部, 講師 (80272962)
ABE Takumi 北海道医療大学, 薬学部, 助教 (80453273)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | インドールアルカロイド / 有機金属試薬 / クロスカップリング / インドリルボレート / ホウ素 / 抗腫瘍活性 / カロトリキシン / エリプチシン / パラジウム触媒 / 銅錯体 / 金属触媒 / ビシクロラクタム / アリール化反応 / セロトニン / 生理活性物質 / クロスカップリング反応 |
|---|
| Research Abstract |
Cross-coupling reaction of indolylborate was used for concise total synththesis of calothrixins A and B. Unprecedented use of CuOTf for 6π-electrocyclization was also found, which was successfully applied for the improved synthesis of ellipticine. Introduction of aryl substituents to bicyclic lactam ABH was performed by metal-catalyzed coupling process.
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